Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Disintegrins MeSH Descriptor Data 2025


MeSH Heading
Disintegrins
Tree Number(s)
D12.644.138
Unique ID
D019483
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019483
Annotation
polypeptides from snake venom; platelet aggregation inhib
Scope Note
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
Entry Term(s)
Disintegrin
Pharm Action
Platelet Aggregation Inhibitors
Registry Numbers
0
Previous Indexing
Peptides (1992-1996)
Venoms (1992-1994)
Public MeSH Note
97; DISINTEGRINS was indexed under PEPTIDES 1992-96 & VENOMS 1992-94
Online Note
use DISINTEGRINS (NM) to search DISINTEGRINS 1992-96
History Note
97; was DISINTEGRINS (NM) 1992-96
Date Established
1997/01/01
Date of Entry
1996/06/10
Revision Date
2020/05/27
Disintegrins Preferred
page delivered in 0.177s