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Trefoil Factors MeSH Descriptor Data 2024

MeSH Heading
Trefoil Factors
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
A family of small peptides expressed primarily by MUCOUS MEMBRANE EPITHELIAL CELLS in vertebrates. Their structure is highly conserved and is defined by a three-leaved (trefoil) domain of 42 or 43 amino acids; it includes six cysteines that create the trefoil structure through disulfide bridges. Trefoil peptides may form dimers with each other, or associate with MUCINS and other factors. They are important for maintaining epithelial integrity and for protection from noxious agents.
Entry Term(s)
TFF Peptide
TFF Peptides
Trefoil Factor
Trefoil Factor Family Peptides
Trefoil Factor Family Proteins
Trefoil Peptide
Trefoil Peptides
Trefoil Protein
Trefoil Proteins
Previous Indexing
Mucins (1992-2016)
Peptides (1992-2016)
Public MeSH Note
History Note
Date Established
Date of Entry
Revision Date
Trefoil Factors Preferred
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