MeSH Browser

MeSH Heading: Clavulanic Acid
Tree Number(s): D02.065.589.099.374.160; D03.633.100.300.374.160
Unique ID: D019818
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019818
Scope Note: A beta-lactam antibiotic produced by the actinobacterium Streptomyces clavuligerus. It is a suicide inhibitor of bacterial beta-lactamase enzymes. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
Entry Term(s): BRL-14151; Clavulanate; Clavulanate Potassium; Clavulanic Acid, Monopotassium Salt; Clavulanic Acid, Monosodium Salt; MM-14151; Potassium Clavulanate; Sodium Clavulanate
Pharm Action: beta-Lactamase Inhibitors
Related Numbers: 57943-81-4; 58001-44-8; 61177-45-5; 85A8F32FMG; Q42OMW3AT8
CAS Type 1 Name: 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha))
Previous Indexing: Clavulanic Acids (1978-1997); Lactams (1976-1982)
Public MeSH Note: 98; CLAVULANIC ACID was indexed under CLAVULANIC ACIDS 1978-97 & LACTAMS 1976-82
History Note: 98; use CLAVULANIC ACID (NM) 1980-97
Entry Combination: analogs & derivatives:Clavulanic Acids
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2018/06/29

Entry Combination: analogs & derivatives:Clavulanic Acids
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Clavulanic Acid MeSH Descriptor Data 2024