MeSH Browser

MeSH Heading: Mitogen-Activated Protein Kinase 1
Tree Number(s): D08.811.913.696.620.682.700.567.249.500; D12.776.476.563.567.249.500
Unique ID: D019950
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019950
Annotation: Don't confuse MAP Kinase 2 with MAP KINASE KINASES referred to as MAP2 Kinases
Scope Note: A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
Entry Term(s): Extracellular Signal-Regulated Kinase 2; MAP Kinase 2; MAPK1 Mitogen-Activated Protein Kinase; MAPK2 Mitogen-Activated Protein Kinase; Mitogen-Activated Protein Kinase 2; p42 MAP Kinase; p42 MAPK; p42(Mapk); p42(Mapk) Kinase; p42(Mitogen-Activated Protein Kinase)
Registry Number: EC 2.7.11.24
Previous Indexing: Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1997); Protein Kinases (1992); Protein-Serine-Threonine Kinases (1993-1995); Protein-Tyrosine Kinase (1992-1997)
Public MeSH Note: 2000; see P42 MAP KINASE 2000-2004, see P42(MAPK) KINASE 1998-1999; P42(MAPK) KINASE was indexed under CALMODULIN-DEPENDENT PROTEIN KINASES 1994-1997, PROTEIN-TYROSINE KINASE 1992-1997, PROTEIN-SERINE-THREONINE KINASES 1993-1995 & PROTEIN KINASES 1992; ERK2 BRAIN KINASE PK40 was indexed under PROTEIN-SERINE-THREONINE KINASES 1995-1999; ERK2 was indexed under CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1998-1999, CALMODULIN-DEPENDENT KINASES 1994-1997, PROTEIN-SERINE-THREONINE KINASES 1992-1993 & PROTEIN KINASES 1992; ERK2 MBP-KINASE was indexed under CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1998-1999 & CALMODULIN-DEPENDENT KINASES 1994-1997
History Note: 2005(1992)
Date Established: 1998/01/01
Date of Entry: 1997/07/02
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
        
        Extracellular Signal-Regulated MAP Kinases [D08.811.913.696.620.682.700.567.249]
        
        Mitogen-Activated Protein Kinase 1 [D08.811.913.696.620.682.700.567.249.500]
        
        Mitogen-Activated Protein Kinase 3 [D08.811.913.696.620.682.700.567.249.750]
        
        Mitogen-Activated Protein Kinase 6 [D08.811.913.696.620.682.700.567.249.875]
        
        Mitogen-Activated Protein Kinase 7 [D08.811.913.696.620.682.700.567.249.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Mitogen-Activated Protein Kinases [D12.776.476.563.567]
        
        Extracellular Signal-Regulated MAP Kinases [D12.776.476.563.567.249]
        
        Mitogen-Activated Protein Kinase 1 [D12.776.476.563.567.249.500]
        
        Mitogen-Activated Protein Kinase 3 [D12.776.476.563.567.249.750]
        
        Mitogen-Activated Protein Kinase 6 [D12.776.476.563.567.249.875]
        
        Mitogen-Activated Protein Kinase 7 [D12.776.476.563.567.249.937]

Mitogen-Activated Protein Kinase 1 Preferred

Concept UI: M0029623
Registry Number: EC 2.7.11.24
Scope Note: A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
Terms: Mitogen-Activated Protein Kinase 1 Preferred Term
Term UI T484423
Date03/04/2002
LexicalTag NON
ThesaurusID NLM (2003); p42 MAPK
Term UI T059472
Date03/03/1997
LexicalTag ABB
ThesaurusID NLM (1998); p42(Mitogen-Activated Protein Kinase)
Term UI T059473
Date03/03/1997
LexicalTag NON
ThesaurusID NLM (1998); p42(Mapk) Kinase
Term UI T059474
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1998); p42 MAP Kinase
Term UI T059476
Date03/03/1997
LexicalTag NON
ThesaurusID NLM (1998); MAPK2 Mitogen-Activated Protein Kinase
Term UI T572658
Date02/13/2004
LexicalTag NON
ThesaurusID NLM (2005); Extracellular Signal-Regulated Kinase 2
Term UI T571696
Date02/06/2004
LexicalTag NON
ThesaurusID NLM (2005); Mitogen-Activated Protein Kinase 2
Term UI T572019
Date02/09/2004
LexicalTag NON
ThesaurusID NLM (2005); MAPK1 Mitogen-Activated Protein Kinase
Term UI T572657
Date02/13/2004
LexicalTag NON
ThesaurusID NLM (2005); p42(Mapk)
Term UI T059471
Date05/28/1997
LexicalTag ABB
ThesaurusID NLM (1998); MAP Kinase 2
Term UI T365004
Date11/05/1999
LexicalTag NON
ThesaurusID NLM (2000)

Mitogen-Activated Protein Kinase 1 MeSH Descriptor Data 2024