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Mitogen-Activated Protein Kinase 1 MeSH Descriptor Data 2025


MeSH Heading
Mitogen-Activated Protein Kinase 1
Tree Number(s)
D08.811.913.696.620.682.700.567.249.500
D12.776.476.563.567.249.500
Unique ID
D019950
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019950
Annotation
Don't confuse MAP Kinase 2 with MAP KINASE KINASES referred to as MAP2 Kinases
Scope Note
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
Entry Term(s)
Extracellular Signal-Regulated Kinase 2
MAP Kinase 2
MAPK1 Mitogen-Activated Protein Kinase
MAPK2 Mitogen-Activated Protein Kinase
Mitogen-Activated Protein Kinase 2
p42 MAP Kinase
p42 MAPK
p42(Mapk)
p42(Mapk) Kinase
p42(Mitogen-Activated Protein Kinase)
Registry Numbers
EC 2.7.11.24
Previous Indexing
Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1997)
Protein Kinases (1992)
Protein-Serine-Threonine Kinases (1993-1995)
Protein-Tyrosine Kinase (1992-1997)
Public MeSH Note
2000; see P42 MAP KINASE 2000-2004, see P42(MAPK) KINASE 1998-1999; P42(MAPK) KINASE was indexed under CALMODULIN-DEPENDENT PROTEIN KINASES 1994-1997, PROTEIN-TYROSINE KINASE 1992-1997, PROTEIN-SERINE-THREONINE KINASES 1993-1995 & PROTEIN KINASES 1992; ERK2 BRAIN KINASE PK40 was indexed under PROTEIN-SERINE-THREONINE KINASES 1995-1999; ERK2 was indexed under CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1998-1999, CALMODULIN-DEPENDENT KINASES 1994-1997, PROTEIN-SERINE-THREONINE KINASES 1992-1993 & PROTEIN KINASES 1992; ERK2 MBP-KINASE was indexed under CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1998-1999 & CALMODULIN-DEPENDENT KINASES 1994-1997
History Note
2005(1992)
Date Established
1998/01/01
Date of Entry
1997/07/02
Revision Date
2021/05/21
Mitogen-Activated Protein Kinase 1 Preferred
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