Receptor, EphA1 MeSH Descriptor Data 2024

MeSH Heading: Receptor, EphA1
Tree Number(s): D08.811.913.696.620.682.725.400.850.050; D12.776.476.568.400.850.050; D12.776.543.750.630.500.050
Unique ID: D036082
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D036082
Scope Note: The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
Entry Version: RECEPT EPHA1
Entry Term(s): EPHA1 Protein; EPHA1 Receptor Tyrosine Kinase; Eph Receptor; EphA1 Receptor
Previous Indexing: Receptor Protein-Tyrosine Kinases (1999-2002)
Public MeSH Note: 2003; EPHA1 PROTEIN (now RECEPTOR, EPHA1) were indexed under RECEPTOR PROTEIN-TYROSINE KINASES 1999-2002
History Note: 2003; use RECEPTOR, EPHA1 (NM) 1999-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        Receptors, Eph Family [D08.811.913.696.620.682.725.400.850]
        
        Receptor, EphA1 [D08.811.913.696.620.682.725.400.850.050]
        
        Receptor, EphA2 [D08.811.913.696.620.682.725.400.850.100]
        
        Receptor, EphA3 [D08.811.913.696.620.682.725.400.850.150]
        
        Receptor, EphA4 [D08.811.913.696.620.682.725.400.850.200]
        
        Receptor, EphA5 [D08.811.913.696.620.682.725.400.850.250]
        
        Receptor, EphA6 [D08.811.913.696.620.682.725.400.850.300]
        
        Receptor, EphA7 [D08.811.913.696.620.682.725.400.850.400]
        
        Receptor, EphA8 [D08.811.913.696.620.682.725.400.850.500]
        
        Receptor, EphB1 [D08.811.913.696.620.682.725.400.850.600]
        
        Receptor, EphB2 [D08.811.913.696.620.682.725.400.850.650]
        
        Receptor, EphB3 [D08.811.913.696.620.682.725.400.850.700]
        
        Receptor, EphB4 [D08.811.913.696.620.682.725.400.850.750]
        
        Receptor, EphB5 [D08.811.913.696.620.682.725.400.850.800]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - Receptor Protein-Tyrosine Kinases [D12.776.476.568.400]
        
        Receptors, Eph Family [D12.776.476.568.400.850]
        
        Receptor, EphA1 [D12.776.476.568.400.850.050]
        
        Receptor, EphA2 [D12.776.476.568.400.850.100]
        
        Receptor, EphA3 [D12.776.476.568.400.850.150]
        
        Receptor, EphA4 [D12.776.476.568.400.850.200]
        
        Receptor, EphA5 [D12.776.476.568.400.850.250]
        
        Receptor, EphA6 [D12.776.476.568.400.850.300]
        
        Receptor, EphA7 [D12.776.476.568.400.850.400]
        
        Receptor, EphA8 [D12.776.476.568.400.850.500]
        
        Receptor, EphB1 [D12.776.476.568.400.850.600]
        
        Receptor, EphB2 [D12.776.476.568.400.850.650]
        
        Receptor, EphB3 [D12.776.476.568.400.850.700]
        
        Receptor, EphB4 [D12.776.476.568.400.850.750]
        
        Receptor, EphB5 [D12.776.476.568.400.850.800]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
        
        Receptors, Eph Family [D12.776.543.750.630.500]
        
        Receptor, EphA1 [D12.776.543.750.630.500.050]
        
        Receptor, EphA2 [D12.776.543.750.630.500.100]
        
        Receptor, EphA3 [D12.776.543.750.630.500.150]
        
        Receptor, EphA4 [D12.776.543.750.630.500.200]
        
        Receptor, EphA5 [D12.776.543.750.630.500.250]
        
        Receptor, EphA6 [D12.776.543.750.630.500.300]
        
        Receptor, EphA7 [D12.776.543.750.630.500.350]
        
        Receptor, EphA8 [D12.776.543.750.630.500.400]
        
        Receptor, EphB1 [D12.776.543.750.630.500.450]
        
        Receptor, EphB2 [D12.776.543.750.630.500.500]
        
        Receptor, EphB3 [D12.776.543.750.630.500.687]
        
        Receptor, EphB4 [D12.776.543.750.630.500.781]
        
        Receptor, EphB5 [D12.776.543.750.630.500.875]
        
        Receptor, EphB6 [D12.776.543.750.630.500.937]

Receptor, EphA1 Preferred

Concept UI: M0333628
Scope Note: The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. Overproduction of the EphA1 receptor is associated with tumors and tumor cells of epithelial origin. It is also expressed at high levels in LIVER; LUNG; and KIDNEY; which is in contrast to many other members of the Eph receptor that are found primarily in tissues of the nervous system.
Terms: Receptor, EphA1 Preferred Term
Term UI T481895
Date02/14/2002
LexicalTag ABX
ThesaurusID NLM (2003); EPHA1 Receptor Tyrosine Kinase
Term UI T365555
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2003); EphA1 Receptor
Term UI T475754
Date01/03/2002
LexicalTag ACX
ThesaurusID NLM (2003); Eph Receptor
Term UI T475783
Date01/03/2002
LexicalTag ACX
ThesaurusID NLM (2003); EPHA1 Protein
Term UI T365554
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003)

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