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Integrin alphaVbeta3 MeSH Descriptor Data 2022


MeSH Heading
Integrin alphaVbeta3
Tree Number(s)
D12.776.395.550.625.439
D12.776.543.550.625.439
D12.776.543.750.705.408.460.870.500
D12.776.543.750.705.675.541
Unique ID
D039302
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D039302
Annotation
do not confuse entry term VITRONECTIN RECEPTOR with VITRONECTIN RECEPTORS
Scope Note
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Entry Term(s)
Integrin alpha-v beta-3
Receptors, alpha-v beta-3 Integrin
Vitronectin Receptor
alpha-v beta-3 Integrin Receptors
Registry Number
0
Public MeSH Note
2003; see RECEPTORS, VITRONECTIN 1996-2002
History Note
2003; use RECEPTORS, VITRONECTIN 1996-2002
Date Established
2003/01/01
Date of Entry
2002/07/02
Revision Date
2013/07/09
Integrin alphaVbeta3 Preferred
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