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Integrin alpha6beta1 MeSH Descriptor Data 2022


MeSH Heading
Integrin alpha6beta1
Tree Number(s)
D12.776.395.550.625.419
D12.776.543.550.625.419
D12.776.543.750.705.408.850.674
D12.776.543.750.705.675.514
D12.776.543.750.705.876.500
Unique ID
D039121
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D039121
Scope Note
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Entry Term(s)
CD49f-CD29
Integrin alpha(6)beta(1)
Integrin alpha6Abeta1
Integrin alpha6Bbeta1
Platelet Glycoprotein I'c-IIa
VLA-6
alpha 6 beta 1 Integrin
alpha6beta1 Integrin
Registry Number
0
Previous Indexing
Integrins (1992-2002)
Public MeSH Note
2003; INTEGRIN ALPHA5BETA1 was indexed under INTEGRINS 1992-2002
History Note
2003; use INTEGRIN ALPHA6BETA1 (NM) 1992-2002
Date Established
2003/01/01
Date of Entry
2002/07/02
Revision Date
2013/07/09
Integrin alpha6beta1 Preferred
Integrin alpha6Bbeta1 Narrower
Integrin alpha6Abeta1 Narrower
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