MeSH Browser

MeSH Heading: Integrin alpha6beta4
Tree Number(s): D12.776.543.750.705.408.460.170; D12.776.543.750.705.876.750
Unique ID: D039161
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039161
Scope Note: This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
Entry Term(s): A9 Antigen; Integrin alpha(6),beta(4); Laminin-5 Receptor (alpha6beta4 Integrin); TSP-180; Tumor Specific Protein-180 Complex; alpha(6)beta(4) Epithelial Integrin; alpha(6)beta(4) Integrin; alpha6 beta4 Integrin
Previous Indexing: Antigens, Surface (1988-2002); Integrins (1988-2002)
Public MeSH Note: 2003; INTEGRIN ALPHA6BETA4 was indexed under INTEGRINS; & ANTIGENS, SURFACE 1988-2002.
History Note: 2003; use INTEGRIN ALPHA6BETA4 (NM) 1988-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0154541
Scope Note: This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
Terms: Integrin alpha6beta4 Preferred Term
Term UI T184546
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); alpha(6)beta(4) Integrin
Term UI T184541
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); alpha6 beta4 Integrin
Term UI T490261
Date04/19/2002
LexicalTag NON
ThesaurusID NLM (2003); Integrin alpha(6),beta(4)
Term UI T184543
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Laminin-5 Receptor (alpha6beta4 Integrin)
Term UI T184544
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); TSP-180
Term UI T184539
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); Tumor Specific Protein-180 Complex
Term UI T184545
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); alpha(6)beta(4) Epithelial Integrin
Term UI T184540
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); A9 Antigen
Term UI T184538
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003)

Integrin alpha6beta4 MeSH Descriptor Data 2024