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This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
Entry Term(s)
A9 Antigen
Integrin alpha(6),beta(4)
Laminin-5 Receptor (alpha6beta4 Integrin)
TSP-180
Tumor Specific Protein-180 Complex
alpha(6)beta(4) Epithelial Integrin
alpha(6)beta(4) Integrin
alpha6 beta4 Integrin
Registry Numbers
0
Previous Indexing
Antigens, Surface (1988-2002)
Integrins (1988-2002)
Public MeSH Note
2003; INTEGRIN ALPHA6BETA4 was indexed under INTEGRINS; & ANTIGENS, SURFACE 1988-2002.
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.