MeSH Browser

MeSH Heading: Integrin alpha1beta1
Tree Number(s): D12.776.543.750.685.100; D12.776.543.750.705.408.850.099; D12.776.543.750.705.876.249
Unique ID: D039222
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039222
Scope Note: Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Entry Term(s): CD49a-CD29; Integrin alpha(1)beta(1); VLA-1; alpha1beta1 Integrin
Previous Indexing: Integrins (1994-2002)
Public MeSH Note: 2003; INTEGRIN ALPHA1BETA1 was indexed under INTEGRINS 1994-2002
History Note: 2003; use INTEGRIN ALPHA1BETA1 (NM) 1994-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2016/06/17

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0230961
Scope Note: Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Terms: Integrin alpha1beta1 Preferred Term
Term UI T260966
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); CD49a-CD29
Term UI T260962
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); alpha1beta1 Integrin
Term UI T260964
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Integrin alpha(1)beta(1)
Term UI T260965
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); VLA-1
Term UI T260963
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003)

Integrin alpha1beta1 MeSH Descriptor Data 2024