MeSH Browser

MeSH Heading: Eukaryotic Initiation Factor-3
Tree Number(s): D12.776.835.725.868.437
Unique ID: D039621
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039621
Scope Note: A multisubunit eukaryotic initiation factor that contains at least 8 distinct polypeptides. It plays a role in recycling of ribosomal subunits to the site of transcription initiation by promoting the dissociation of non-translating ribosomal subunits. It also is involved in promoting the binding of a ternary complex of EUKARYOTIC INITIATION FACTOR-2; GTP; and INITIATOR TRNA to the 40S ribosomal subunit.
Entry Term(s): EIF-3; EIF3; EIF3 p110; EIF3 p42 Protein; EIF3-alpha; EIF3-beta; EIF3-epsilon; EIF3-gamma; EIF3-p48; EIF3-zeta; EIF3S3 Gene Product; EIF3S3 Protein; EIF3S4 Protein; Eukaryotic Initiation Factor-3 p110; Eukaryotic Initiation Factor-3, Subunit 1; Eukaryotic Initiation Factor-3, Subunit 2; Eukaryotic Initiation Factor-3, Subunit 3; Eukaryotic Initiation Factor-3, Subunit 4; Eukaryotic Initiation Factor-3, Subunit 5; Eukaryotic Initiation Factor-3, Subunit 6; Eukaryotic Initiation Factor-3, Subunit 7; Eukaryotic Initiation Factor-3, Subunit 8; Eukaryotic Initiation Factor-3, beta Subunit; Eukaryotic Initiation Factor-3, delta Subunit; Eukaryotic Initiation Factor-3, gamma Subunit; Eukaryotic Initiation Factor-3, zeta Subunit; Eukaryotic Peptide Initiation Factor 3, Subunit 5; Eukaryotic Peptide Initiation Factor-3; Eukaryotic Peptide Initiation Factor-3, Subunit 1; Eukaryotic Peptide Initiation Factor-3, Subunit 2; Eukaryotic Peptide Initiation Factor-3, Subunit 3; Eukaryotic Peptide Initiation Factor-3, Subunit 4; Eukaryotic Peptide Initiation Factor-3, alpha Subunit; Eukaryotic Translation Initiation Factor-3, Subunit 8; INT6 Protein; Int-6 Gene Product; Int-6 Protein; Peptide Initiation Factor EIF-3; p42 EIF3 Protein
Registry Number: 0
Previous Indexing: Peptide Initiation Factors (1990-2002)
Public MeSH Note: 2003; EIF-3 (now EUKARYOTIC INITIATION FACTOR-3) was indexed under PEPTIDE INITIATION FACTORS 1990-2002; EUKARYOTIC INITIATION FACTOR 3 P110 (now EUKARYOTIC INITIATION FACTOR-3) was indexed under PEPTIDE INITIATION FACTORS 2000-2002; EUKARYOTIC INITIATION FACTOR 3, SUBUNIT 4 (now EUKARYOTIC INITIATION FACTOR-3) was indexed under PEPTIDE INITIATION FACTORS 1999-2002; INT-6 PROTEIN (now EUKARYOTIC INITIATION FACTOR-3) was indexed under PEPTIDE INITIATION FACTORS 1995-2002
History Note: 2003; use EUKARYOTIC INITIATION FACTOR-3 (NM) 1990-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Ribosomal Proteins [D12.776.835]
    - Peptide Initiation Factors [D12.776.835.725]
      - Eukaryotic Initiation Factors [D12.776.835.725.868]
        
        Eukaryotic Initiation Factor-1 [D12.776.835.725.868.124]
        
        Eukaryotic Initiation Factor-2 [D12.776.835.725.868.249]
        
        Eukaryotic Initiation Factor-2B [D12.776.835.725.868.374]
        
        Eukaryotic Initiation Factor-3 [D12.776.835.725.868.437]
        
        Eukaryotic Initiation Factor-4F [D12.776.835.725.868.500]
        
        Eukaryotic Initiation Factor-5 [D12.776.835.725.868.750]

Eukaryotic Initiation Factor-3 Preferred

Concept UI: M0177967
Registry Number: 0
Scope Note: A multisubunit eukaryotic initiation factor that contains at least 8 distinct polypeptides. It plays a role in recycling of ribosomal subunits to the site of transcription initiation by promoting the dissociation of non-translating ribosomal subunits. It also is involved in promoting the binding of a ternary complex of EUKARYOTIC INITIATION FACTOR-2; GTP; and INITIATOR TRNA to the 40S ribosomal subunit.
Terms: Eukaryotic Initiation Factor-3 Preferred Term
Term UI T207968
LexicalTag NON
ThesaurusID NLM (2003); Peptide Initiation Factor EIF-3
Term UI T489286
Date04/12/2002
LexicalTag ACX
ThesaurusID NLM (2003); Eukaryotic Peptide Initiation Factor-3
Term UI T489287
Date04/12/2002
LexicalTag NON
ThesaurusID NLM (2003); EIF-3
Term UI T207972
LexicalTag ACR
ThesaurusID NLM (2003); EIF3
Term UI T108903
LexicalTag ACR
ThesaurusID NLM (2003)

Eukaryotic Initiation Factor-3, Subunit 2 Narrower

Eukaryotic Initiation Factor-3, Subunit 3 Narrower

Eukaryotic Initiation Factor-3, Subunit 8 Narrower

Eukaryotic Initiation Factor-3, Subunit 5 Narrower

Eukaryotic Initiation Factor-3, Subunit 6 Narrower

Concept UI: M0242820
Registry Number: 0
Terms: Eukaryotic Initiation Factor-3, Subunit 6 Preferred Term
Term UI T489180
Date04/11/2002
LexicalTag NON
ThesaurusID NLM (2003); INT6 Protein
Term UI T489181
Date04/11/2002
LexicalTag ACX
ThesaurusID NLM (2003); Int-6 Protein
Term UI T272825
LexicalTag ACX
ThesaurusID NLM (2003); EIF3-p48
Term UI T272824
LexicalTag ACR
ThesaurusID NLM (2003); Int-6 Gene Product
Term UI T272823
LexicalTag ACX
ThesaurusID NLM (2003)

Eukaryotic Initiation Factor-3, Subunit 7 Narrower

Eukaryotic Initiation Factor-3, Subunit 1 Narrower

Eukaryotic Initiation Factor-3, Subunit 4 Narrower

Eukaryotic Initiation Factor-3 MeSH Descriptor Data 2024