MeSH Browser

MeSH Heading: Eukaryotic Initiation Factor-5
Tree Number(s): D12.644.360.325.150.300; D12.776.476.325.150.300; D12.776.835.725.868.750
Unique ID: D040061
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D040061
Scope Note: A eukaryotic initiation factor that interacts with the 40S initiation complex and promotes the hydrolysis of the bound GTP. The hydrolysis of GTP causes the release of EUKARYOTIC INITIATION FACTOR-2 and EUKARYOTIC INITIATION FACTOR-3 from the 40S subunit and the subsequent joining of the 60S ribosomal subunit to the 40S complex to form the functional 80S initiation complex
Entry Term(s): EIF-5; Eukaryotic Peptide Initiation Factor-5; Peptide Initiation Factor EIF-5
Pharm Action: GTP Phosphohydrolase Activators
Previous Indexing: Peptide Initiation Factors (1982-2002)
Public MeSH Note: 2003; EIF-5 (now EUKARYOTIC INITIATION FACTOR-5) was indexed under PEPTIDE INITIATION FACTORS 1982-2002
History Note: 2003; use EUKARYOTIC INITIATION FACTOR-5 (NM) 1982-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0110035
Scope Note: A eukaryotic initiation factor that interacts with the 40S initiation complex and promotes the hydrolysis of the bound GTP. The hydrolysis of GTP causes the release of EUKARYOTIC INITIATION FACTOR-2 and EUKARYOTIC INITIATION FACTOR-3 from the 40S subunit and the subsequent joining of the 60S ribosomal subunit to the 40S complex to form the functional 80S initiation complex
Terms: Eukaryotic Initiation Factor-5 Preferred Term
Term UI T489323
Date04/12/2002
LexicalTag NON
ThesaurusID NLM (2003); EIF-5
Term UI T140039
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); Peptide Initiation Factor EIF-5
Term UI T489324
Date04/12/2002
LexicalTag ACX
ThesaurusID NLM (2003); Eukaryotic Peptide Initiation Factor-5
Term UI T489345
Date04/12/2002
LexicalTag NON
ThesaurusID NLM (2003)

Eukaryotic Initiation Factor-5 MeSH Descriptor Data 2024