MeSH Browser

MeSH Heading: Metabolic Detoxication, Phase I
Tree Number(s): G03.171.450.500; G03.787.225.450.500; G07.690.725.225.450.500
Unique ID: D050216
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050216
Scope Note: Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
Entry Version: METAB DETOX PHASE I
Entry Term(s): Metabolic Detoxication, Oxidative; Metabolic Detoxification, Phase I; Phase I Detoxification
See Also: Drug Interactions
Public MeSH Note: 2006
History Note: 2006
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/06/30

Allowable Qualifiers: ethnology (EH)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0473292
Scope Note: Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
Terms: Metabolic Detoxication, Phase I Preferred Term
Term UI T611357
Date09/29/2004
LexicalTag NON
ThesaurusID NLM (2006); Metabolic Detoxification, Phase I
Term UI T611358
Date09/29/2004
LexicalTag NON
ThesaurusID NLM (2006); Metabolic Detoxication, Oxidative
Term UI T611380
Date09/29/2004
LexicalTag NON
ThesaurusID NLM (2006); Phase I Detoxification
Term UI T626001
Date12/27/2004
LexicalTag NON
ThesaurusID NLM (2006)

Metabolic Detoxication, Phase I MeSH Descriptor Data 2025