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A component of NF-kappa B transcription factor. It is proteolytically processed from NF-kappa B p105 precursor protein and is capable of forming dimeric complexes with itself or with TRANSCRIPTION FACTOR RELA. It regulates expression of GENES involved in immune and inflammatory responses.
Entry Term(s)
NF-kappa B p105 Precursor Protein
NF-kappa B p50
NF-kappaB 50-kDa
NFKB1 Transcription Factor
Registry Numbers
0
Public MeSH Note
2006; NF-KAPPA B P50 SUBUNIT was indexed under NF-KAPPA B & PROTEIN PRECURSORS 1992-2005
A component of NF-kappa B transcription factor. It is proteolytically processed from NF-kappa B p105 precursor protein and is capable of forming dimeric complexes with itself or with TRANSCRIPTION FACTOR RELA. It regulates expression of GENES involved in immune and inflammatory responses.
NF-kappa B p105 precursor protein is constitutively processed by the PROTEASOME to produce NF-kappa B p50 subunit. It helps regulate map kinase signaling through its association with Map3k8 protein.