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A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2).
Entry Term(s)
Apo C-III
Apo C-III-2
ApoC-III
Apolipoprotein C-III-0
Apolipoprotein C-III-1
Apolipoprotein CIII
Sialyl Apo C-III
Sialyl Apolipoprotein C-III
Registry Numbers
0
Previous Indexing
Apolipoproteins C (1977-2006)
Public MeSH Note
2007; APOLIPOPROTEIN C-III was indexed under APOLIPOPROTEINS C 1985-2006 & under APOLIPOPROTEINS 1979-1984
A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2).