MeSH Browser

MeSH Heading: Matrix Metalloproteinase 14
Tree Number(s): D08.811.277.656.300.480.525.300.500; D08.811.277.656.675.374.525.300.500
Unique ID: D053511
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053511
Scope Note: A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Entry Term(s): MMP-14 Metalloproteinase; MMP-X1 Protein; MMP14 Metalloproteinase; MT-MMP-1; MT1-MMP; MT1-Matrix Metalloproteinase; Membrane-Type 1 Matrix Metalloproteinase; Membrane-Type Matrix Metalloproteinase 1
Registry Number: EC 3.4.24.80
Public MeSH Note: 2007; MATRIX METALLOPROTEINASE 14 was indexed under MATRIX METALLOPROTEINASES 2006 & under METALLOENDOPEPTIDASES 1994-2005
History Note: 2007(1994)
Entry Combination: antagonists & inhibitors:Matrix Metalloproteinase Inhibitors
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2012/07/03

Entry Combination: antagonists & inhibitors:Matrix Metalloproteinase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0286947
Registry Number: EC 3.4.24.80
Scope Note: A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Terms: Matrix Metalloproteinase 14 Preferred Term
Term UI T262708
LexicalTag NON
ThesaurusID NLM (2007); Membrane-Type Matrix Metalloproteinase 1
Term UI T642814
Date06/10/2005
LexicalTag NON
ThesaurusID NLM (2007); MMP-14 Metalloproteinase
Term UI T664575
Date01/18/2006
LexicalTag ABX
ThesaurusID NLM (2007); MT1-MMP
Term UI T316950
LexicalTag ABB
ThesaurusID NLM (2007); MMP14 Metalloproteinase
Term UI T664593
Date01/18/2006
LexicalTag ABX
ThesaurusID NLM (2007); MT-MMP-1
Term UI T316949
LexicalTag ABB
ThesaurusID NLM (2007); MT1-Matrix Metalloproteinase
Term UI T316951
LexicalTag ABX
ThesaurusID NLM (2007); Membrane-Type 1 Matrix Metalloproteinase
Term UI T316952
LexicalTag NON
ThesaurusID NLM (2007); MMP-X1 Protein
Term UI T262702
LexicalTag ABX
ThesaurusID NLM (2007)

Matrix Metalloproteinase 14 MeSH Descriptor Data 2024