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Presenilin-1 MeSH Descriptor Data 2023


MeSH Heading
Presenilin-1
Tree Number(s)
D12.776.543.696.500
Unique ID
D053764
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053764
Scope Note
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.
Entry Term(s)
Presenilin 1
S182 Protein
Registry Number
0
Previous Indexing
Alzheimer Disease (1995-2006)
Membrane Proteins (1995-2006)
Public MeSH Note
2007; was indexed under MEMBRANE PROTEINS 1995-2006
History Note
2007
Date Established
2007/01/01
Date of Entry
2006/07/05
Revision Date
2010/06/25
Presenilin-1 Preferred
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