MeSH Browser

MeSH Heading: Presenilin-1
Tree Number(s): D12.776.543.696.500
Unique ID: D053764
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053764
Scope Note: Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.
Entry Term(s): Presenilin 1; S182 Protein
Registry Numbers: 0
Previous Indexing: Alzheimer Disease (1995-2006); Membrane Proteins (1995-2006)
Public MeSH Note: 2007; was indexed under MEMBRANE PROTEINS 1995-2006
History Note: 2007
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2010/06/25

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0248671
Registry Numbers: 0
Scope Note: Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.
Terms: Presenilin-1 Preferred Term
Term UI T418310
Date07/06/2000
LexicalTag NON
ThesaurusID NLM (2007); Presenilin 1
Term UI T408355
Date03/02/2000
LexicalTag NON
ThesaurusID NLM (2007); S182 Protein
Term UI T278676
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007)

Presenilin-1 MeSH Descriptor Data 2025