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Presenilin-2 MeSH Descriptor Data 2022


MeSH Heading
Presenilin-2
Tree Number(s)
D12.776.543.696.750
Unique ID
D053766
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053766
Scope Note
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.
Entry Term(s)
Presenilin 2
Registry Number
0
Previous Indexing
Alzheimer Disease (1996-2006)
Membrane Proteins (1996-2006)
Public MeSH Note
2007; was indexed under MEMBRANE PROTEINS 1996-2006
History Note
2007
Date Established
2007/01/01
Date of Entry
2006/07/05
Revision Date
2010/06/25
Presenilin-2 Preferred
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