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Lissencephaly MeSH Descriptor Data 2024


MeSH Heading
Lissencephaly
Tree Number(s)
C10.500.507.450.499
C16.131.666.507.450.499
Unique ID
D054082
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054082
Annotation
note specifics; MICROLISSENCEPHALY see MICROCEPHALY is also available
Scope Note
A smooth brain malformation of the CEREBRAL CORTEX resulting from the abnormal location of developing neurons during corticogenesis. It is characterized by an absence of normal convoluted indentations on the surface of the brain (agyria), or fewer and shallower indentations (pachygryia). There is a reduced number of cortical layers, typically 4 instead of 6, resulting in a thickened cortex, and reduced cerebral white matter that is a reversal of the normal ratio of cerebral white matter to cortex.
Entry Term(s)
Agyria
Broad Gyri of Cerebrum
Large Gyri of Cerebrum
Lissencephalia
Macrogyria
Pachygyria
Public MeSH Note
2008
History Note
2008
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2016/02/26
Lissencephaly Preferred
Agyria Related
Pachygyria Related
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