NLM Logo

Classical Lissencephalies and Subcortical Band Heterotopias MeSH Descriptor Data 2022


MeSH Heading
Classical Lissencephalies and Subcortical Band Heterotopias
Tree Number(s)
C10.500.507.450.230
C10.500.507.450.499.230
C16.131.666.507.450.230
C16.131.666.507.450.499.230
C16.320.322.500.186
Unique ID
D054221
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054221
Scope Note
Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)
Entry Term(s)
Agyria-Pachygyria-Band Spectrum
Chromosome 17p13.3 Deletion Syndrome
Classic Lissencephaly
Classical Lissencephaly Syndrome
Double Cortex Syndrome
Heterotopia, Subcortical Band
Isolated Lissencephaly Sequence
Lissencephalies, Classical
Lissencephaly 1
Lissencephaly Sequence, Isolated
Lissencephaly Syndrome, Miller-Dieker
Lissencephaly Type 1
Lissencephaly, Classic
Lissencephaly, Miller-Dieker
Lissencephaly, Type 1
Lissencephaly, X-Linked
Lissencephaly, X-Linked, 1
Lissencephaly-Subcortical Band Heterotopia
Miller-Dieker Lissencephaly Syndrome
Miller-Dieker Syndrome
Subcortical Band Heterotopia
Subcortical Laminar Heterotopia
Type 1 Lissencephaly
X-Linked Lissencephaly
Previous Indexing
Cerebral Cortex/abnormalities (1993-2007)
Public MeSH Note
2008
History Note
2008
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2018/10/10
Classical Lissencephalies and Subcortical Band Heterotopias Preferred
X-Linked Lissencephaly Narrower
Lissencephaly Syndrome, Miller-Dieker Narrower
Subcortical Band Heterotopia Narrower
Lissencephaly, X-Linked, 1 Narrower
Lissencephalies, Classical Narrower
page delivered in 0.136s