MeSH Browser

MeSH Heading: Classical Lissencephalies and Subcortical Band Heterotopias
Tree Number(s): C10.500.507.450.230; C10.500.507.450.499.230; C16.131.666.507.450.230; C16.131.666.507.450.499.230; C16.320.322.500.186
Unique ID: D054221
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054221
Scope Note: Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)
Entry Term(s): Agyria-Pachygyria-Band Spectrum; Chromosome 17p13.3 Deletion Syndrome; Classic Lissencephaly; Classical Lissencephaly Syndrome; Double Cortex Syndrome; Heterotopia, Subcortical Band; Isolated Lissencephaly Sequence; Lissencephalies, Classical; Lissencephaly 1; Lissencephaly Sequence, Isolated; Lissencephaly Syndrome, Miller-Dieker; Lissencephaly Type 1; Lissencephaly, Classic; Lissencephaly, Miller-Dieker; Lissencephaly, Type 1; Lissencephaly, X-Linked; Lissencephaly, X-Linked, 1; Lissencephaly-Subcortical Band Heterotopia; Miller-Dieker Lissencephaly Syndrome; Miller-Dieker Syndrome; Subcortical Band Heterotopia; Subcortical Laminar Heterotopia; Type 1 Lissencephaly; X-Linked Lissencephaly
Previous Indexing: Cerebral Cortex/abnormalities (1993-2007)
Public MeSH Note: 2008
History Note: 2008
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2018/10/10

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Nervous System Malformations [C10.500]
  - Malformations of Cortical Development [C10.500.507]
    - Malformations of Cortical Development, Group II [C10.500.507.450]

Nervous System Diseases [C10]
- Nervous System Malformations [C10.500]
  - Malformations of Cortical Development [C10.500.507]
    - Malformations of Cortical Development, Group II [C10.500.507.450]
      - Lissencephaly [C10.500.507.450.499]
        
        Classical Lissencephalies and Subcortical Band Heterotopias [C10.500.507.450.499.230]
        
        Cobblestone Lissencephaly [C10.500.507.450.499.249]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Congenital Abnormalities [C16.131]
  - Nervous System Malformations [C16.131.666]
    - Malformations of Cortical Development [C16.131.666.507]
      - Malformations of Cortical Development, Group II [C16.131.666.507.450]
        
        Classical Lissencephalies and Subcortical Band Heterotopias [C16.131.666.507.450.230]
        
        Cobblestone Lissencephaly [C16.131.666.507.450.249]
        
        Lissencephaly [C16.131.666.507.450.499]
        
        Periventricular Nodular Heterotopia [C16.131.666.507.450.750]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Congenital Abnormalities [C16.131]
  - Nervous System Malformations [C16.131.666]
    - Malformations of Cortical Development [C16.131.666.507]
      - Malformations of Cortical Development, Group II [C16.131.666.507.450]
        
        Lissencephaly [C16.131.666.507.450.499]
        
        Classical Lissencephalies and Subcortical Band Heterotopias [C16.131.666.507.450.499.230]
        
        Cobblestone Lissencephaly [C16.131.666.507.450.499.249]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Genetic Diseases, X-Linked [C16.320.322]
    - Mental Retardation, X-Linked [C16.320.322.500]

Classical Lissencephalies and Subcortical Band Heterotopias Preferred

Concept UI: M0501375
Scope Note: Disorders comprising a spectrum of brain malformations representing the paradigm of a diffuse neuronal migration disorder. They result in cognitive impairment; SEIZURES; and HYPOTONIA or spasticity. Mutations of two genes, LIS1, the gene for the non-catalytic subunit of PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB; and DCX or XLIS, the gene for doublecortin, have been identified as the most common causes of disorders in this spectrum. Additional variants of classical (Type I) lissencephaly have been linked to RELN, the gene for reelin, and ARX, the gene for aristaless related homeobox protein. (From Leventer, R.J., et al, Mol Med Today. 2000 Jul;6(7):277-84 and Barkovich, A.J., et al, Neurology. 2005 Dec 27;65(12):1873-87.)
Terms: Classical Lissencephalies and Subcortical Band Heterotopias Preferred Term
Term UI T684521
Date10/24/2006
LexicalTag NON
ThesaurusID NLM (2008); Agyria-Pachygyria-Band Spectrum
Term UI T684522
Date10/24/2006
LexicalTag NON
ThesaurusID NLM (2008); Lissencephaly-Subcortical Band Heterotopia
Term UI T684523
Date10/24/2006
LexicalTag NON
ThesaurusID NLM (2008)

Lissencephaly Syndrome, Miller-Dieker Narrower

Subcortical Band Heterotopia Narrower

X-Linked Lissencephaly Narrower

Lissencephalies, Classical Narrower

Concept UI: M0503208
Terms: Lissencephalies, Classical Preferred Term
Term UI T680774
Date09/01/2006
LexicalTag NON
ThesaurusID NLM (2008); Isolated Lissencephaly Sequence
Term UI T680776
Date09/01/2006
LexicalTag NON
ThesaurusID NLM (2008); Lissencephaly 1
Term UI T812642
Date11/15/2011
LexicalTag NON
ThesaurusID OMIM (2013); Lissencephaly Sequence, Isolated
Term UI T812643
Date11/15/2011
LexicalTag NON
ThesaurusID OMIM (2013); Lissencephaly, Classic
Term UI T812644
Date11/15/2011
LexicalTag NON
ThesaurusID OMIM (2013); Lissencephaly, Type 1
Term UI T680786
Date09/05/2006
LexicalTag NON
ThesaurusID NLM (2008); Type 1 Lissencephaly
Term UI T680775
Date09/01/2006
LexicalTag NON
ThesaurusID NLM (2008); Classical Lissencephaly Syndrome
Term UI T842013
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); Classic Lissencephaly
Term UI T842756
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); Lissencephaly Type 1
Term UI T842757
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014)

Lissencephaly, X-Linked, 1 Narrower

Classical Lissencephalies and Subcortical Band Heterotopias MeSH Descriptor Data 2024