MeSH Browser

MeSH Heading: Mucopolysaccharidosis II
Tree Number(s): C10.597.606.360.455.750; C16.320.322.500.750; C16.320.400.525.750; C16.320.565.202.715.645; C16.320.565.595.600.645; C17.300.550.575.645; C18.452.648.202.715.645; C18.452.648.595.600.645
Unique ID: D016532
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016532
Scope Note: Systemic lysosomal storage disease marked by progressive physical deterioration and caused by a deficiency of L-sulfoiduronate sulfatase. This disease differs from MUCOPOLYSACCHARIDOSIS I by slower progression, lack of corneal clouding, and X-linked rather than autosomal recessive inheritance. The mild form produces near-normal intelligence and life span. The severe form usually causes death by age 15.
Entry Version: MPS II
Entry Term(s): Gargoylism, Hunter Syndrome; Hunter Syndrome; Hunter Syndrome Gargoylism; Hunter's Syndrome; I2S Deficiency; Iduronate 2-Sulfatase Deficiency; Iduronate Sulfatase Deficiency; Mucopolysaccharidosis 2; Mucopolysaccharidosis Type 2; Mucopolysaccharidosis Type II; Sulfoiduronate Sulfatase Deficiency
Previous Indexing: Mucopolysaccharidosis I (1966-1991)
See Also: Iduronate Sulfatase; Mucopolysaccharidosis I
Public MeSH Note: 1992; for MUCOPOLYSACCHARIDOSIS 2 and HUNTER'S SYNDROME see LIPOCHONDRODYSTROPHY 1976-1991
History Note: 1992; for MUCOPOLYSACCHARIDOSIS 2 and HUNTER'S SYNDROME use LIPOCHONDRODYSTROPHY 1976-1991
Date Established: 1992/01/01
Date of Entry: 1991/06/21
Revision Date: 2018/07/01

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Neurologic Manifestations [C10.597]
  - Neurobehavioral Manifestations [C10.597.606]
    - Intellectual Disability [C10.597.606.360]
      - Mental Retardation, X-Linked [C10.597.606.360.455]
        
        Adrenoleukodystrophy [C10.597.606.360.455.124]
        
        Coffin-Lowry Syndrome [C10.597.606.360.455.249]
        
        Fragile X Syndrome [C10.597.606.360.455.500]
        
        Glycogen Storage Disease Type IIb [C10.597.606.360.455.562]
        
        Lesch-Nyhan Syndrome [C10.597.606.360.455.625]
        
        Menkes Kinky Hair Syndrome [C10.597.606.360.455.687]
        
        Mucopolysaccharidosis II [C10.597.606.360.455.750]
        
        Pyruvate Dehydrogenase Complex Deficiency Disease [C10.597.606.360.455.875]
        
        Rett Syndrome [C10.597.606.360.455.937]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Genetic Diseases, X-Linked [C16.320.322]
    - Mental Retardation, X-Linked [C16.320.322.500]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Heredodegenerative Disorders, Nervous System [C16.320.400]
    - Mental Retardation, X-Linked [C16.320.400.525]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Carbohydrate Metabolism, Inborn Errors [C16.320.565.202]
      - Mucopolysaccharidoses [C16.320.565.202.715]
        
        Mucopolysaccharidosis I [C16.320.565.202.715.640]
        
        Mucopolysaccharidosis II [C16.320.565.202.715.645]
        
        Mucopolysaccharidosis III [C16.320.565.202.715.650]
        
        Mucopolysaccharidosis IV [C16.320.565.202.715.655]
        
        Mucopolysaccharidosis VI [C16.320.565.202.715.670]
        
        Mucopolysaccharidosis VII [C16.320.565.202.715.675]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Lysosomal Storage Diseases [C16.320.565.595]
      - Mucopolysaccharidoses [C16.320.565.595.600]
        
        Mucopolysaccharidosis I [C16.320.565.595.600.640]
        
        Mucopolysaccharidosis II [C16.320.565.595.600.645]
        
        Mucopolysaccharidosis III [C16.320.565.595.600.650]
        
        Mucopolysaccharidosis IV [C16.320.565.595.600.655]
        
        Mucopolysaccharidosis VI [C16.320.565.595.600.670]
        
        Mucopolysaccharidosis VII [C16.320.565.595.600.675]

Skin and Connective Tissue Diseases [C17]
- Connective Tissue Diseases [C17.300]
  - Mucinoses [C17.300.550]
    - Mucopolysaccharidoses [C17.300.550.575]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Carbohydrate Metabolism, Inborn Errors [C18.452.648.202]
      - Mucopolysaccharidoses [C18.452.648.202.715]
        
        Mucopolysaccharidosis I [C18.452.648.202.715.640]
        
        Mucopolysaccharidosis II [C18.452.648.202.715.645]
        
        Mucopolysaccharidosis III [C18.452.648.202.715.650]
        
        Mucopolysaccharidosis IV [C18.452.648.202.715.655]
        
        Mucopolysaccharidosis VI [C18.452.648.202.715.670]
        
        Mucopolysaccharidosis VII [C18.452.648.202.715.675]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Lysosomal Storage Diseases [C18.452.648.595]
      - Mucopolysaccharidoses [C18.452.648.595.600]
        
        Mucopolysaccharidosis I [C18.452.648.595.600.640]
        
        Mucopolysaccharidosis II [C18.452.648.595.600.645]
        
        Mucopolysaccharidosis III [C18.452.648.595.600.650]
        
        Mucopolysaccharidosis IV [C18.452.648.595.600.655]
        
        Mucopolysaccharidosis VI [C18.452.648.595.600.670]
        
        Mucopolysaccharidosis VII [C18.452.648.595.600.675]

Mucopolysaccharidosis II Preferred

Concept UI: M0025232
Scope Note: Systemic lysosomal storage disease marked by progressive physical deterioration and caused by a deficiency of L-sulfoiduronate sulfatase. This disease differs from MUCOPOLYSACCHARIDOSIS I by slower progression, lack of corneal clouding, and X-linked rather than autosomal recessive inheritance. The mild form produces near-normal intelligence and life span. The severe form usually causes death by age 15.
Terms: Mucopolysaccharidosis II Preferred Term
Term UI T049455
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1992); Mucopolysaccharidosis 2
Term UI T049456
Date09/11/1990
LexicalTag NON
ThesaurusID NLM (1992); Gargoylism, Hunter Syndrome
Term UI T443707
Date04/20/2001
LexicalTag EPO
ThesaurusID NLM (2002); Hunter Syndrome Gargoylism
Term UI T443708
Date04/20/2001
LexicalTag EPO
ThesaurusID NLM (2002); Mucopolysaccharidosis Type 2
Term UI T752466
Date06/08/2009
LexicalTag NON
ThesaurusID; Mucopolysaccharidosis Type II
Term UI T844075
Date05/13/2013
LexicalTag NON
ThesaurusID GHR (2014); Hunter's Syndrome
Term UI T049454
Date09/11/1990
LexicalTag EPO
ThesaurusID; Hunter Syndrome
Term UI T844076
Date05/13/2013
LexicalTag NON
ThesaurusID GHR (2014)

Sulfoiduronate Sulfatase Deficiency Related

Mucopolysaccharidosis II MeSH Descriptor Data 2024