MeSH Browser

MeSH Heading: Glutaredoxins
Tree Number(s): D08.811.682.667.084
Unique ID: D054477
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054477
Scope Note: A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.
Entry Term(s): Glutaredoxin; Glutaredoxin 1; Glutaredoxin 2; Glutaredoxin 3; Glutaredoxin 5; TTase-1; Thioltransferase; Thioltransferase-1
Public MeSH Note: 2008; GLUTAREDOXINS were indexed under OXIDOREDUCTASES 2005-2007 & under PROTEINS 1979-2004; THIOLTRANSFERASE was indexed under SULFHYDRYL COMPOUNDS 1978-1981; under OXIDOREDUCTASES 1982-2004 & under PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE) 2005-2007
History Note: 2008(1980); use PROTEINS 1979
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0071848
Scope Note: A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.
Terms: Glutaredoxins Preferred Term
Term UI T689010
Date01/09/2007
LexicalTag NON
ThesaurusID NLM (2008); Glutaredoxin
Term UI T101851
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Thioltransferase
Term UI T109273
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008)

Glutaredoxins MeSH Descriptor Data 2024