MeSH Browser

MeSH Heading: Hydroxymethylglutaryl-CoA Synthase
Tree Number(s): D08.811.913.050.612
Unique ID: D006904
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006904
Scope Note: An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.
Entry Version: HMG COA SYNTHASE
Entry Term(s): 3-hydroxy-3-methylglutaryl-coenzyme A synthase; HMG CoA Synthase; HMG-CoA synthase
Registry Number: EC 2.3.3.10
Related Numbers: 9027-44-5
CAS Type 1 Name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)
Previous Indexing: Coenzyme A (1973-1974); Glutarates (1973-1974); Ketoacid-Lyases (1973-1974)
Public MeSH Note: 1991; HMG-COA SYNTHASE was indexed under HYDROXYMETHYLGLUTARYL-COA SYNTHASE 2005-2008, & under COENZYME A LIGASES 2001-2005
History Note: 1991(1975);
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2019/04/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0010773
Registry Number: EC 2.3.3.10
Related Numbers: 9027-44-5
Scope Note: An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.
Terms: Hydroxymethylglutaryl-CoA Synthase Preferred Term
Term UI T020786
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1975); 3-hydroxy-3-methylglutaryl-coenzyme A synthase
Term UI T463133
Date09/25/2001
LexicalTag NON
ThesaurusID NLM (2009); HMG-CoA synthase
Term UI T463132
Date09/25/2001
LexicalTag NON
ThesaurusID NLM (2009); HMG CoA Synthase
Term UI T000952289
Date02/28/2019
LexicalTag ABX
ThesaurusID NLM (2020)

Hydroxymethylglutaryl-CoA Synthase MeSH Descriptor Data 2024