MeSH Browser

MeSH Heading: 5-Aminolevulinate Synthetase
Tree Number(s): D08.811.913.050.276
Unique ID: D000624
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000624
Scope Note: An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Entry Term(s): 5-Aminolevulinate Synthase; Aminolevulinic Acid Synthetase; delta-Aminolevulinate Synthase; delta-Aminolevulinic Acid Synthetase
Related Numbers: 9037-14-3
CAS Type 1 Name: Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating)
Previous Indexing: Acyltransferases (1966-1971)
Public MeSH Note: 98; see AMINOLEVULINIC ACID SYNTHETASE 1972-97
History Note: 98(72)
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2007/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0000954
Related Numbers: 9037-14-3
Scope Note: An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.
Terms: 5-Aminolevulinate Synthetase Preferred Term
Term UI T001869
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1972); Aminolevulinic Acid Synthetase
Term UI T001866
Date12/03/1996
LexicalTag NON
ThesaurusID NLM (1998); delta-Aminolevulinate Synthase
Term UI T001867
Date05/01/1997
LexicalTag NON
ThesaurusID NLM (1998); delta-Aminolevulinic Acid Synthetase
Term UI T001868
Date06/25/1981
LexicalTag NON
ThesaurusID UNK (19XX); 5-Aminolevulinate Synthase
Term UI T694436
Date03/27/2007
LexicalTag NON
ThesaurusID NLM (2008)

5-Aminolevulinate Synthetase MeSH Descriptor Data 2024