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Phosphatidylcholine-Sterol O-Acyltransferase MeSH Descriptor Data 2024


MeSH Heading
Phosphatidylcholine-Sterol O-Acyltransferase
Tree Number(s)
D08.811.913.050.625
Unique ID
D007862
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007862
Scope Note
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.
Entry Term(s)
Cholesterol Ester Lysolecithin Acyltransferase
Lecithin Acyltransferase
Lecithin Cholesterol Acyltransferase
Phosophatidylcholine-Sterol Acyltransferase
Registry Number
EC 2.3.1.43
Related Numbers
9031-14-5
CAS Type 1 Name
Phosphatidylcholine:sterol O-acyltransferase
NLM Classification #
QU 141
Previous Indexing
Acyltransferases (1966-1974)
Cholesterol (1966-1974)
Phosphatidylcholines (1966-1974)
Public MeSH Note
98; see LECITHIN ACYLTRANSFERASE 1978-97; see ACYLTRANSFERASES 1975-77
History Note
98(75)
Entry Combination
deficiency:Lecithin Cholesterol Acyltransferase Deficiency
Date Established
1978/01/01
Date of Entry
1974/11/11
Revision Date
2016/07/01
Phosphatidylcholine-Sterol O-Acyltransferase Preferred
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