MeSH Browser

MeSH Heading: Phosphatidylcholine-Sterol O-Acyltransferase
Tree Number(s): D08.811.913.050.625
Unique ID: D007862
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007862
Scope Note: An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.
Entry Term(s): Cholesterol Ester Lysolecithin Acyltransferase; Lecithin Acyltransferase; Lecithin Cholesterol Acyltransferase; Phosophatidylcholine-Sterol Acyltransferase
Related Numbers: 9031-14-5
CAS Type 1 Name: Phosphatidylcholine:sterol O-acyltransferase
NLM Classification #: QU 141
Previous Indexing: Acyltransferases (1966-1974); Cholesterol (1966-1974); Phosphatidylcholines (1966-1974)
Public MeSH Note: 98; see LECITHIN ACYLTRANSFERASE 1978-97; see ACYLTRANSFERASES 1975-77
History Note: 98(75)
Entry Combination: deficiency:Lecithin Cholesterol Acyltransferase Deficiency
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2016/07/01

Entry Combination: deficiency:Lecithin Cholesterol Acyltransferase Deficiency
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0012276
Related Numbers: 9031-14-5
Scope Note: An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma.
Terms: Phosphatidylcholine-Sterol O-Acyltransferase Preferred Term
Term UI T023455
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Lecithin Acyltransferase
Term UI T000903455
Date06/30/2016
LexicalTag NON
ThesaurusID NLM (1998); Cholesterol Ester Lysolecithin Acyltransferase
Term UI T023451
Date07/31/1980
LexicalTag NON
ThesaurusID UNK (19XX); Lecithin Cholesterol Acyltransferase
Term UI T023453
Date02/06/1975
LexicalTag NON
ThesaurusID UNK (19XX); Phosophatidylcholine-Sterol Acyltransferase
Term UI T023454
Date09/24/1986
LexicalTag NON
ThesaurusID UNK (19XX)

Phosphatidylcholine-Sterol O-Acyltransferase MeSH Descriptor Data 2024