MeSH Browser

MeSH Heading: Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
Tree Number(s): D08.811.682.690.708.660
Unique ID: D008240
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D008240
Scope Note: A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.
Entry Term(s): Collagen Lysyl Hydroxylase; Lysine 2-Oxoglutarate Dioxygenase; Lysine Hydroxylase; Lysyl Hydroxylase; Protocollagen Lysyl Hydroxylase
CAS Type 1 Name: Procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Previous Indexing: Hydroxylases (1966-1976); Ketoglutaric Acids (1966-1976); Lysine (1966-1976)
Public MeSH Note: 92; was LYSINE HYDROXYLASE 1977-91 (see under HYDROXYLASES 1977-90)
Online Note: use PROCOLLAGEN-LYSINE, 2-OXOGLUTARATE 5-DIOXYGENASE to search LYSINE HYDROXYLASE 1977-91
History Note: 92; was LYSINE HYDROXYLASE 1977-91 (see under HYDROXYLASES 1977-90)
Date Established: 1991/01/01
Date of Entry: 1976/04/27
Revision Date: 2004/07/07

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0012838
Scope Note: A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.
Terms: Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase Preferred Term
Term UI T024564
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); Collagen Lysyl Hydroxylase
Term UI T024559
Date01/03/1985
LexicalTag NON
ThesaurusID UNK (19XX); Lysine 2-Oxoglutarate Dioxygenase
Term UI T024560
Date04/26/1976
LexicalTag NON
ThesaurusID UNK (19XX); Lysine Hydroxylase
Term UI T024561
Date01/15/1991
LexicalTag NON
ThesaurusID NLM (1992); Lysyl Hydroxylase
Term UI T024562
Date06/07/1989
LexicalTag NON
ThesaurusID NLM (1990); Protocollagen Lysyl Hydroxylase
Term UI T024563
Date04/26/1976
LexicalTag NON
ThesaurusID UNK (19XX)

Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase MeSH Descriptor Data 2024