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The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
Entry Term(s)
Squalene Epoxidase
Squalene Monooxygenase (2,3-Epoxidizing)
Registry Numbers
EC 1.14.14.17
Related Numbers
9029-62-3
Public MeSH Note
2006; SQUALENE MONOOXYGENASE was indexed under OXYGENASES 1981-2005 & ETHERS, CYCLIC 1970-1980
The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.