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Zidovudine MeSH Descriptor Data 2023


MeSH Heading
Zidovudine
Tree Number(s)
D03.383.742.680.705.950
D13.570.230.500.950
D13.570.230.855.950
D13.570.685.705.950
Unique ID
D015215
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015215
Scope Note
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.
Entry Term(s)
3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
AZT (Antiviral)
AZT Antiviral
AZT, Antiviral
Azidothymidine
BW A509U
BWA-509U
Retrovir
Pharm Action
Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Registry Number
4B9XT59T7S
Related Numbers
30516-87-1
CAS Type 1 Name
Thymidine, 3'-azido-3'-deoxy-
Previous Indexing
Thymidine/analogs & derivatives (1975-1988)
Public MeSH Note
89
History Note
89
Date Established
1989/01/01
Date of Entry
1988/05/09
Revision Date
2016/06/01
Zidovudine Preferred
Retrovir Related
BW A509U Narrower
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