MeSH Browser

MeSH Heading: Perilipins
Tree Number(s): D12.776.157.464.500
Unique ID: D000070137
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000070137
Scope Note: A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.
Entry Term(s): PAT Proteins; PLIN Proteins; Perilipin Proteins; Perilipin-Adipophilin-TIP47 Proteins
Registry Numbers: 0
Previous Indexing: Carrier Proteins (1991-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/01/19

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000609416
Registry Numbers: 0
Scope Note: A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.
Terms: Perilipins Preferred Term
Term UI T000885892
Date08/31/2015
LexicalTag NON
ThesaurusID NLM (2017); PAT Proteins
Term UI T000885893
Date08/31/2015
LexicalTag ACX
ThesaurusID NLM (2017); Perilipin Proteins
Term UI T000885894
Date08/31/2015
LexicalTag NON
ThesaurusID NLM (2017); PLIN Proteins
Term UI T000885895
Date08/31/2015
LexicalTag ABX
ThesaurusID NLM (2017); Perilipin-Adipophilin-TIP47 Proteins
Term UI T000890129
Date11/06/2015
LexicalTag ABX
ThesaurusID NLM (2017)

Perilipins MeSH Descriptor Data 2025