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MutL Protein Homolog 1 MeSH Descriptor Data 2025


MeSH Heading
MutL Protein Homolog 1
Tree Number(s)
D08.811.074.766.500
D08.811.277.040.025.215.500
D12.776.260.540.500
Unique ID
D000070957
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000070957
Scope Note
Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.
Entry Term(s)
COCA2 Protein
Colon Cancer, Nonpolyposis Type 2 Protein
MLH1 Protein
MutL Homolog 1
Registry Numbers
EC 3.6.1.3
Previous Indexing
Adaptor Proteins, Signal Transducing (1994-2016)
Nuclear Proteins (1995-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/02/26
MutL Protein Homolog 1 Preferred
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