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Forkhead Box Protein O1 MeSH Descriptor Data 2022


MeSH Heading
Forkhead Box Protein O1
Tree Number(s)
D12.776.260.950.249.250
D12.776.930.977.249.250
Unique ID
D000071161
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071161
Scope Note
A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.
Entry Term(s)
FOXO1 Protein
Forkhead in Rhabdomyosarcoma Protein
Registry Number
0
Previous Indexing
Forkhead Transcription Factors (2006-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/02/26
Forkhead Box Protein O1 Preferred
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