MeSH Browser

MeSH Heading: Forkhead Box Protein O1
Tree Number(s): D12.776.260.950.249.250; D12.776.930.977.249.250
Unique ID: D000071161
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071161
Scope Note: A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.
Entry Term(s): FOXO1 Protein; Forkhead in Rhabdomyosarcoma Protein
Registry Numbers: 0
Previous Indexing: Forkhead Transcription Factors (2006-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/26

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000613324
Registry Numbers: 0
Scope Note: A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.
Terms: Forkhead Box Protein O1 Preferred Term
Term UI T000893127
Date01/04/2016
LexicalTag NON
ThesaurusID NLM (2017); FOXO1 Protein
Term UI T000893128
Date01/04/2016
LexicalTag NON
ThesaurusID NLM (2017); Forkhead in Rhabdomyosarcoma Protein
Term UI T000893129
Date01/04/2016
LexicalTag NON
ThesaurusID NLM (2017)

Forkhead Box Protein O1 MeSH Descriptor Data 2025