MeSH Browser

MeSH Heading: Forkhead Box Protein L2
Tree Number(s): D12.776.260.950.249.032; D12.776.930.977.249.032
Unique ID: D000074842
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074842
Scope Note: A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure).
Entry Term(s): FOXL2 Protein; Forkhead Box L2 Protein
Registry Numbers: 0
Previous Indexing: Forkhead Transcription Factors (2006-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/05/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000628267
Registry Numbers: 0
Scope Note: A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure).
Terms: Forkhead Box Protein L2 Preferred Term
Term UI T000919181
Date03/15/2017
LexicalTag NON
ThesaurusID NLM (2018); FOXL2 Protein
Term UI T000919182
Date03/15/2017
LexicalTag ABX
ThesaurusID NLM (2018); Forkhead Box L2 Protein
Term UI T000919183
Date03/15/2017
LexicalTag NON
ThesaurusID NLM (2018)

Forkhead Box Protein L2 MeSH Descriptor Data 2025