MeSH Browser

MeSH Heading: Prion Proteins
Tree Number(s): D09.400.430.890.448.600; D12.776.395.550.448.600; D12.776.543.484.500.625; D12.776.543.550.418.600; D12.776.785.340
Unique ID: D000072002
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072002
Scope Note: Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is characterized by five TANDEM REPEAT SEQUENCES that encode a highly unstable protein region of five octapeptide repeats. Mutations in the repeat region and elsewhere in this gene are associated with CREUTZFELDT-JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN-STRAUSSLER DISEASE; Huntington disease-like 1, and KURU.
Entry Term(s): AltPrP; Alternative Prion Protein; CD230 Antigen; Creutzfeldt-Jakob Disease Protein; Fatal Familial Insomnia Protein; Major Prion Protein; PrP Proteins; Prion Protein
Previous Indexing: Prions (2006-2016)
Public MeSH Note: 2017; for PRION PROTEINS see PRIONS 1991-2016
History Note: 2017: for PRION PROTEINS use PRIONS 1991-2016
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - GPI-Linked Proteins [D09.400.430.890.448]
        
        Lipopolysaccharide Receptors [D09.400.430.890.448.100]
        
        CD24 Antigen [D09.400.430.890.448.120]
        
        CD55 Antigens [D09.400.430.890.448.130]
        
        CD59 Antigens [D09.400.430.890.448.140]
        
        Bone Marrow Stromal Antigen 2 [D09.400.430.890.448.150]
        
        Carbonic Anhydrase IV [D09.400.430.890.448.160]
        
        CD48 Antigen [D09.400.430.890.448.180]
        
        CD52 Antigen [D09.400.430.890.448.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D09.400.430.890.448.200]
        
        Contactins [D09.400.430.890.448.250]
        
        Ephrin-A1 [D09.400.430.890.448.300]
        
        Ephrin-A2 [D09.400.430.890.448.310]
        
        Ephrin-A3 [D09.400.430.890.448.320]
        
        Ephrin-A4 [D09.400.430.890.448.330]
        
        Ephrin-A5 [D09.400.430.890.448.340]
        
        Folate Receptors, GPI-Anchored [D09.400.430.890.448.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D09.400.430.890.448.400]
        
        Glypicans [D09.400.430.890.448.500]
        
        Mesothelin [D09.400.430.890.448.550]
        
        Prion Proteins [D09.400.430.890.448.600]
        
        Matrix Metalloproteinase 17 [D09.400.430.890.448.700]
        
        Nogo Receptors [D09.400.430.890.448.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D09.400.430.890.448.775]
        
        Receptors, Urokinase Plasminogen Activator [D09.400.430.890.448.813]
        
        Uromodulin [D09.400.430.890.448.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - GPI-Linked Proteins [D12.776.395.550.448]
        
        Lipopolysaccharide Receptors [D12.776.395.550.448.100]
        
        CD24 Antigen [D12.776.395.550.448.120]
        
        CD55 Antigens [D12.776.395.550.448.130]
        
        CD59 Antigens [D12.776.395.550.448.140]
        
        Bone Marrow Stromal Antigen 2 [D12.776.395.550.448.150]
        
        Carbonic Anhydrase IV [D12.776.395.550.448.160]
        
        CD48 Antigen [D12.776.395.550.448.180]
        
        CD52 Antigen [D12.776.395.550.448.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.395.550.448.200]
        
        Contactins [D12.776.395.550.448.250]
        
        Ephrin-A1 [D12.776.395.550.448.300]
        
        Ephrin-A2 [D12.776.395.550.448.310]
        
        Ephrin-A3 [D12.776.395.550.448.320]
        
        Ephrin-A4 [D12.776.395.550.448.330]
        
        Ephrin-A5 [D12.776.395.550.448.340]
        
        Folate Receptors, GPI-Anchored [D12.776.395.550.448.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.395.550.448.400]
        
        Glypicans [D12.776.395.550.448.500]
        
        Mesothelin [D12.776.395.550.448.550]
        
        Prion Proteins [D12.776.395.550.448.600]
        
        Matrix Metalloproteinase 17 [D12.776.395.550.448.700]
        
        Nogo Receptors [D12.776.395.550.448.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D12.776.395.550.448.775]
        
        Receptors, Urokinase Plasminogen Activator [D12.776.395.550.448.813]
        
        Uromodulin [D12.776.395.550.448.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Lipid-Linked Proteins [D12.776.543.484]
      - GPI-Linked Proteins [D12.776.543.484.500]
        
        Lipopolysaccharide Receptors [D12.776.543.484.500.100]
        
        CD24 Antigen [D12.776.543.484.500.120]
        
        CD55 Antigens [D12.776.543.484.500.130]
        
        CD59 Antigens [D12.776.543.484.500.140]
        
        Bone Marrow Stromal Antigen 2 [D12.776.543.484.500.150]
        
        Carbonic Anhydrase IV [D12.776.543.484.500.160]
        
        CD48 Antigen [D12.776.543.484.500.180]
        
        CD52 Antigen [D12.776.543.484.500.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.543.484.500.200]
        
        Contactins [D12.776.543.484.500.250]
        
        Ephrin-A1 [D12.776.543.484.500.300]
        
        Ephrin-A2 [D12.776.543.484.500.310]
        
        Ephrin-A3 [D12.776.543.484.500.320]
        
        Ephrin-A4 [D12.776.543.484.500.330]
        
        Ephrin-A5 [D12.776.543.484.500.340]
        
        Folate Receptors, GPI-Anchored [D12.776.543.484.500.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.543.484.500.400]
        
        Glypicans [D12.776.543.484.500.550]
        
        Mesothelin [D12.776.543.484.500.588]
        
        Prion Proteins [D12.776.543.484.500.625]
        
        Matrix Metalloproteinase 17 [D12.776.543.484.500.700]
        
        Nogo Receptors [D12.776.543.484.500.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D12.776.543.484.500.775]
        
        Receptors, Urokinase Plasminogen Activator [D12.776.543.484.500.813]
        
        Uromodulin [D12.776.543.484.500.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - GPI-Linked Proteins [D12.776.543.550.418]
        
        Lipopolysaccharide Receptors [D12.776.543.550.418.100]
        
        CD24 Antigen [D12.776.543.550.418.120]
        
        CD55 Antigens [D12.776.543.550.418.130]
        
        CD59 Antigens [D12.776.543.550.418.140]
        
        Bone Marrow Stromal Antigen 2 [D12.776.543.550.418.150]
        
        Carbonic Anhydrase IV [D12.776.543.550.418.160]
        
        CD48 Antigen [D12.776.543.550.418.180]
        
        CD52 Antigen [D12.776.543.550.418.190]
        
        Ciliary Neurotrophic Factor Receptor alpha Subunit [D12.776.543.550.418.200]
        
        Contactins [D12.776.543.550.418.250]
        
        Ephrin-A1 [D12.776.543.550.418.300]
        
        Ephrin-A2 [D12.776.543.550.418.310]
        
        Ephrin-A3 [D12.776.543.550.418.320]
        
        Ephrin-A4 [D12.776.543.550.418.330]
        
        Ephrin-A5 [D12.776.543.550.418.340]
        
        Folate Receptors, GPI-Anchored [D12.776.543.550.418.370]
        
        Glial Cell Line-Derived Neurotrophic Factor Receptors [D12.776.543.550.418.400]
        
        Glypicans [D12.776.543.550.418.500]
        
        Mesothelin [D12.776.543.550.418.550]
        
        Prion Proteins [D12.776.543.550.418.600]
        
        Matrix Metalloproteinase 17 [D12.776.543.550.418.700]
        
        Nogo Receptors [D12.776.543.550.418.738]
        
        Oligodendrocyte-Myelin Glycoprotein [D12.776.543.550.418.775]
        
        Receptors, Urokinase Plasminogen Activator [D12.776.543.550.418.813]
        
        Uromodulin [D12.776.543.550.418.850]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Prions [D12.776.785]
    - Prion Proteins [D12.776.785.340]
      - PrPC Proteins [D12.776.785.340.500]
      - PrPSc Proteins [D12.776.785.340.750]

Prion Proteins Preferred

Concept UI: M000616231
Scope Note: Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is characterized by five TANDEM REPEAT SEQUENCES that encode a highly unstable protein region of five octapeptide repeats. Mutations in the repeat region and elsewhere in this gene are associated with CREUTZFELDT-JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN-STRAUSSLER DISEASE; Huntington disease-like 1, and KURU.
Terms: Prion Proteins Preferred Term
Term UI T033391
Date10/11/1991
LexicalTag NON
ThesaurusID NLM (1993); PrP Proteins
Term UI T033392
Date12/07/1993
LexicalTag NON
ThesaurusID NLM (1995); Fatal Familial Insomnia Protein
Term UI T000897859
Date03/29/2016
LexicalTag NON
ThesaurusID NLM (2017); Prion Protein
Term UI T000897856
Date03/29/2016
LexicalTag NON
ThesaurusID NLM (2017); CD230 Antigen
Term UI T000897857
Date03/29/2016
LexicalTag ABX
ThesaurusID NLM (2017); Creutzfeldt-Jakob Disease Protein
Term UI T000897858
Date03/29/2016
LexicalTag NON
ThesaurusID NLM (2017); Major Prion Protein
Term UI T000897855
Date03/29/2016
LexicalTag NON
ThesaurusID NLM (2017)

Alternative Prion Protein Related

Prion Proteins MeSH Descriptor Data 2024