MeSH Browser

MeSH Heading: Sodium-Hydrogen Exchanger 3
Tree Number(s): D12.776.157.530.450.162.775.750; D12.776.157.530.937.703.750; D12.776.543.550.190.775.750; D12.776.543.585.450.162.775.750; D12.776.543.585.937.828.750
Unique ID: D000074083
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074083
Scope Note: A sodium-hydrogen antiporter expressed primarily by EPITHELIAL CELLS in the kidneys, it localizes to the apical membrane of the PROXIMAL KIDNEY TUBULE, where it functions in sodium and water reabsorption and possibly calcium homeostasis. It also is expressed in heart, brain, and lung tissues and is resistant to AMILORIDE inhibition.
Entry Term(s): NHE-3 Protein; Na(+)-H(+) Exchanger 3; SLC9A3 Protein; Solute Carrier Family 9 Member 3
Public MeSH Note: 2018; SODIUM-HYDROGEN EXCHANGER 3 was indexed under SODIUM-HYDROGEN EXCHANGERS 1994-2017
History Note: 2018 (1994)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000625448
Scope Note: A sodium-hydrogen antiporter expressed primarily by EPITHELIAL CELLS in the kidneys, it localizes to the apical membrane of the PROXIMAL KIDNEY TUBULE, where it functions in sodium and water reabsorption and possibly calcium homeostasis. It also is expressed in heart, brain, and lung tissues and is resistant to AMILORIDE inhibition.
Terms: Sodium-Hydrogen Exchanger 3 Preferred Term
Term UI T000913999
Date01/11/2017
LexicalTag NON
ThesaurusID NLM (1994); NHE-3 Protein
Term UI T000914000
Date01/11/2017
LexicalTag ABX
ThesaurusID NLM (2000); SLC9A3 Protein
Term UI T000914001
Date01/11/2017
LexicalTag ABX
ThesaurusID NLM (2018); Solute Carrier Family 9 Member 3
Term UI T000914002
Date01/11/2017
LexicalTag NON
ThesaurusID NLM (2018); Na(+)-H(+) Exchanger 3
Term UI T000914003
Date01/11/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Sodium-Hydrogen Exchanger 3 MeSH Descriptor Data 2024