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Sodium-Hydrogen Exchanger 3 MeSH Descriptor Data 2025
A sodium-hydrogen antiporter expressed primarily by EPITHELIAL CELLS in the kidneys, it localizes to the apical membrane of the PROXIMAL KIDNEY TUBULE, where it functions in sodium and water reabsorption and possibly calcium homeostasis. It also is expressed in heart, brain, and lung tissues and is resistant to AMILORIDE inhibition.
Entry Term(s)
NHE-3 Protein
Na(+)-H(+) Exchanger 3
SLC9A3 Protein
Solute Carrier Family 9 Member 3
Registry Numbers
0
Public MeSH Note
2018; SODIUM-HYDROGEN EXCHANGER 3 was indexed under SODIUM-HYDROGEN EXCHANGERS 1994-2017
A sodium-hydrogen antiporter expressed primarily by EPITHELIAL CELLS in the kidneys, it localizes to the apical membrane of the PROXIMAL KIDNEY TUBULE, where it functions in sodium and water reabsorption and possibly calcium homeostasis. It also is expressed in heart, brain, and lung tissues and is resistant to AMILORIDE inhibition.