MeSH Browser

MeSH Heading: Pradimicins and Benanomicins
Tree Number(s): D02.455.426.559.847.562.050.825; D02.540.576.750; D02.806.550.469; D04.345.674.750; D04.615.562.050.825; D09.408.051.059.825
Unique ID: D000095643
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000095643
Scope Note: Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria, e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g., D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins and benanomicins have anti-HIV activities.
Entry Term(s): Benanomicin Antibiotics; Benanomicin and Pradimicin Antibiotics; Benanomicinones; Benanomicins; Benanomicins and Pradimicins; Pradimicin Antibiotics; Pradimicin and Benanomicin Antibiotics; Pradimicin-Like Polyketides; Pradimicin-Type Polyphenols; Pradimicinones; Pradimicins
Public MeSH Note: 2024
History Note: 2024
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/06/14

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M000758716
Scope Note: Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria, e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g., D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins and benanomicins have anti-HIV activities.
Terms: Pradimicins and Benanomicins Preferred Term
Term UI T001124861
Date09/19/2022
LexicalTag NON
ThesaurusID NLM (2024); Pradimicin-Like Polyketides
Term UI T001124859
Date09/19/2022
LexicalTag NON
ThesaurusID NLM (2024); Pradimicin-Type Polyphenols
Term UI T001124860
Date09/19/2022
LexicalTag NON
ThesaurusID NLM (2024); Benanomicins and Pradimicins
Term UI T001124862
Date09/19/2022
LexicalTag NON
ThesaurusID NLM (2024)

Pradimicins and Benanomicins MeSH Descriptor Data 2024