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Polyether Polyketides MeSH Descriptor Data 2024


MeSH Heading
Polyether Polyketides
Tree Number(s)
D02.355.291.933
D02.540.576.625
D04.345.241.654
D04.345.674.625
Unique ID
D000095662
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000095662
Scope Note
Polycyclic polyketides with distinctive ladder shaped multiple polyether motifs. In STREPTOMYCES polycyclic polyketide backbones are assembled by type I modular polyketide synthases which then are modified by epoxidase and epoxide hydrolase to achieve their stereochemistry. Polyether ionophore antibiotics coordinate alkali metal cations with their multiple oxygen atoms which disturbs sodium/potassium concentration gradient. They are widely used to treat and control COCCIDIOSIS. Structurally related MARINE LADDER POLYETHERS are neurotoxins.
Entry Term(s)
Marine Ladder Polyethers
Polyether Antibiotics
Polyether Ionophore Antibiotics
Polyether Ionophores
Registry Number
0
Public MeSH Note
2024
History Note
2024
Date Established
2024/01/01
Date of Entry
2023/07/26
Revision Date
2023/02/26
Polyether Polyketides Preferred
Polyether Antibiotics Narrower
Marine Ladder Polyethers Narrower
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