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Chediak-Higashi Syndrome MeSH Descriptor Data 2023


MeSH Heading
Chediak-Higashi Syndrome
Tree Number(s)
C11.270.040.772
C15.378.553.774.257
C16.320.798.375
C20.673.774.257
C20.673.795.375
Unique ID
D002609
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D002609
Scope Note
A form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections. In many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions. The disease is transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle.
Entry Term(s)
Chediak-Steinbrinck-Higashi Syndrome
Oculocutaneous Albinism with Leukocyte Defect
NLM Classification #
QW 740
Previous Indexing
Immunologic Deficiency Syndromes (1968-1970)
Leukocytes (1966-1970)
See Also
Aleutian Mink Disease
Public MeSH Note
71
History Note
71
Date Established
1971/01/01
Date of Entry
1999/01/01
Revision Date
2019/06/17
Chediak-Higashi Syndrome Preferred
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