MeSH Browser

MeSH Heading: Microbial Collagenase
Tree Number(s): D08.811.277.656.300.480.205.500; D08.811.277.656.675.374.205.500
Unique ID: D003012
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003012
Scope Note: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
Entry Term(s): Clostridiopeptidase A; Clostridium histolyticum Collagenase; Collagenase Clostridium histolyticum; Collagenase, Microbial; Collagenase-Like Peptidase; Collalysine; Nucleolysin
Registry Number: EC 3.4.24.3
NLM Classification #: QU 136
Public MeSH Note: 94; was CLOSTRIDIUM HISTOLYTICUM COLLAGENASE 1991-93; was CLOSTRIDIOPEPTIDASE A 1963-90
Online Note: use MICROBIAL COLLAGENASE to search CLOSTRIDIUM HISTOLYTICUM COLLAGENASE 1991-93 & CLOSTRIDIOPEPTIDASE A 1966-90
History Note: 94; was CLOSTRIDIUM HISTOLYTICUM COLLAGENASE 1991-93; was CLOSTRIDIOPEPTIDASE A 1963-90
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2014/06/12

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0004633
Registry Number: EC 3.4.24.3
Scope Note: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
Terms: Microbial Collagenase Preferred Term
Term UI T008758
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1963); Clostridium histolyticum Collagenase
Term UI T008756
Date09/21/1992
LexicalTag NON
ThesaurusID NLM (1994); Nucleolysin
Term UI T008755
Date10/07/1986
LexicalTag NON
ThesaurusID UNK (19XX); Collagenase, Microbial
Term UI T008757
Date10/13/1992
LexicalTag NON
ThesaurusID NLM (1994); Collalysine
Term UI T008754
Date06/08/1981
LexicalTag NON
ThesaurusID UNK (19XX); Clostridiopeptidase A
Term UI T008753
Date04/04/1990
LexicalTag NON
ThesaurusID NLM (1991); Collagenase Clostridium histolyticum
Term UI T848277
Date08/23/2013
LexicalTag NON
ThesaurusID NLM (2015)

Microbial Collagenase MeSH Descriptor Data 2024