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Debrisoquin MeSH Descriptor Data 2022


MeSH Heading
Debrisoquin
Tree Number(s)
D03.633.100.531.205
Unique ID
D003647
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D003647
Scope Note
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Entry Term(s)
Debrisoquine
Tendor
Pharm Action
Antihypertensive Agents
Sympatholytics
Adrenergic Agents
Registry Number
X31CDK040E
Related Numbers
1131-64-2
CAS Type 1 Name
2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-
Previous Indexing
Antihypertensive Agents (1966-1972)
Isoquinolines (1969-1972)
Public MeSH Note
91; was see under ISOQUINOLINES 1973-90
History Note
91(73); was see under ISOQUINOLINES 1973-90
Date Established
1991/01/01
Date of Entry
1999/01/01
Revision Date
2016/05/28
Debrisoquin Preferred
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