MeSH Browser

MeSH Heading: Nomifensine
Tree Number(s): D03.633.100.531.535
Unique ID: D009627
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D009627
Scope Note: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
Entry Term(s): Hoe-984; Linamiphen; Merital; Nomifensin; Nomifensine Maleate; Nomifensine Maleate (1:1)
Pharm Action: Dopamine Uptake Inhibitors
Related Numbers: 24526-64-5; 32795-47-4; 76S8CUH5MR
CAS Type 1 Name: 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-
Previous Indexing: Isoquinolines (1969-1977); Quinolines (1966-1968)
Public MeSH Note: 86; was see under ISOQUINOLINES 1978-85
History Note: 86(78); was see under ISOQUINOLINES 1978-85
Date Established: 1986/01/01
Date of Entry: 1977/04/22
Revision Date: 2016/05/31

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0014947
Related Numbers: 24526-64-5; 32795-47-4; 76S8CUH5MR
Scope Note: An isoquinoline derivative that prevents dopamine reuptake into synaptosomes. The maleate was formerly used in the treatment of depression. It was withdrawn worldwide in 1986 due to the risk of acute hemolytic anemia with intravascular hemolysis resulting from its use. In some cases, renal failure also developed. (From Martindale, The Extra Pharmacopoeia, 30th ed, p266)
Terms: Nomifensine Preferred Term
Term UI T028633
Date01/01/1999
LexicalTag NON
ThesaurusID; Linamiphen
Term UI T028632
Date01/14/1987
LexicalTag NON
ThesaurusID UNK (19XX); Nomifensin
Term UI T028634
Date04/18/1977
LexicalTag NON
ThesaurusID UNK (19XX)

Nomifensine MeSH Descriptor Data 2024