MeSH Browser

MeSH Heading: Diphtheria Toxin
Tree Number(s): D08.811.913.400.725.115.220; D23.946.123.305
Unique ID: D004167
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004167
Annotation: /antag permitted but consider also DIPHTHERIA ANTITOXIN
Scope Note: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
Entry Term(s): Corynebacterium Diphtheriae Toxin; Toxin, Corynebacterium Diphtheriae
Pharm Action: Poisons
NLM Classification #: WC 320
See Also: Diphtheria Toxoid
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2007/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0006522
Scope Note: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
Terms: Diphtheria Toxin Preferred Term
Term UI T012659
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Corynebacterium Diphtheriae Toxin
Term UI T012658
Date06/17/1985
LexicalTag NON
ThesaurusID UNK (19XX); Toxin, Corynebacterium Diphtheriae
Term UI T012657
Date11/05/1990
LexicalTag NON
ThesaurusID NLM (1992)

Diphtheria Toxin MeSH Descriptor Data 2024