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Cholera Toxin MeSH Descriptor Data 2023


MeSH Heading
Cholera Toxin
Tree Number(s)
D08.811.913.400.725.115.180
D23.946.123.194
D23.946.330.150
Unique ID
D002772
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D002772
Annotation
/antag permitted but consider also ANTITOXINS
Scope Note
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Entry Term(s)
Cholera Enterotoxin CT
Cholera Exotoxin
Cholera Toxin A
Cholera Toxin A Subunit
Cholera Toxin B
Cholera Toxin B Subunit
Cholera Toxin Protomer A
Cholera Toxin Protomer B
Cholera Toxin Subunit A
Cholera Toxin Subunit B
Choleragen
Choleragenoid
Procholeragenoid
Pharm Action
Adjuvants, Immunologic
Poisons
Registry Number
9012-63-9
Related Numbers
EC 2.4.2.31
NLM Classification #
WC 262
Previous Indexing
Bacterial Proteins (1966-1977)
Bacterial Toxins (1977)
Enterotoxins (1966-1977)
Toxins (1966-1967)
Public MeSH Note
78
History Note
78
Date Established
1978/01/01
Date of Entry
1977/04/22
Revision Date
2021/06/30
Cholera Toxin Preferred
Choleragenoid Narrower
Procholeragenoid Narrower
Cholera Toxin Protomer A Narrower
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