MeSH Browser

MeSH Heading: ADP Ribose Transferases
Tree Number(s): D08.811.913.400.725.115
Unique ID: D036002
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D036002
Scope Note: Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.
Entry Term(s): ADP Ribose Transferase; ADP-Ribosyltransferase; ADPRT; ADPRTs; ART Transferase; ART Transferases; ARTase; ARTases; Mono ADP-ribose Transferases; Mono ADPribose Transferase; Mono ADPribose Transferases; Mono(ADP-Ribose) Transferase; Mono(ADP-Ribose) Transferases; Mono(ADP-Ribosyl)transferase; Mono(ADPribosyl)transferase; Mono-ADP-Ribosyltransferase; MonoADPribosyltransferase; NAD ADP-Ribosyltransferase; NAD(+)-L-arginine ADP-D-ribosyltransferase; NAD(P)(+)-Arginine ADP-Ribosyltransferase; NAD+ ADP-Ribosyltransferase; NAD-Agmatine ADP-Ribosyltransferase; NAD-Arginine ADP-Ribosyltransferase; NADP-ADPRTase; NADP-Arginine ADP-Ribosyltransferase
Related Numbers: 81457-93-4; EC 2.4.2.31
See Also: ADP-Ribosylation
Public MeSH Note: 2003; see NAD(P)(+)-ARGININE ADP-RIBOSYLTRANSFERASE 1992-2002, see NAD-ARGININE ADP-RIBOSYLTRANSFERASE 1989-1991; for NAD+ ADP-RIBOSYLTRANSFERASE see NAD+ ADP-RIBOSYLTRANSFERASE 1992-2002, see POLY ADP RIBOSE POLYMERASE 1988-1991; for MONO-ADP-RIBOSYLTRANSFERASE and NAD-ARGININE ADP-RIBOSYLTRANSFERASE and NADP-ARGININE ADP-RIBOSYLTRANSFERASE see NAD(P)(+)-ARGININE ADP-RIBOSYLTRANSFERASE 1992-2002, see NAD-ARGININE ADP-RIBOSYLTRANSFERASE 1989-1991
History Note: 2003; for NAD+ ADP-RIBOSYLTRANSFERASE use POLY(ADP-RIBOSE) POLYMERASES 1988-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2017/04/14

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Glycosyltransferases [D08.811.913.400]
      - Pentosyltransferases [D08.811.913.400.725]
        
        Adenine Phosphoribosyltransferase [D08.811.913.400.725.100]
        
        ADP Ribose Transferases [D08.811.913.400.725.115]
        
        Cholera Toxin [D08.811.913.400.725.115.180]
        
        Diphtheria Toxin [D08.811.913.400.725.115.220]
        
        NAD+ Nucleosidase [D08.811.913.400.725.115.660]
        
        Pertussis Toxin [D08.811.913.400.725.115.680]
        
        Poly(ADP-ribose) Polymerases [D08.811.913.400.725.115.690]
        
        Pseudomonas aeruginosa Exotoxin A [D08.811.913.400.725.115.826]
        
        Sirtuins [D08.811.913.400.725.115.961]
        
        Amidophosphoribosyltransferase [D08.811.913.400.725.130]
        
        Anthranilate Phosphoribosyltransferase [D08.811.913.400.725.160]
        
        ATP Phosphoribosyltransferase [D08.811.913.400.725.200]
        
        Hypoxanthine Phosphoribosyltransferase [D08.811.913.400.725.450]
        
        Nicotinamide Phosphoribosyltransferase [D08.811.913.400.725.575]
        
        Orotate Phosphoribosyltransferase [D08.811.913.400.725.700]
        
        Purine-Nucleoside Phosphorylase [D08.811.913.400.725.800]
        
        Pyrimidine Phosphorylases [D08.811.913.400.725.850]
        
        UDP Xylose-Protein Xylosyltransferase [D08.811.913.400.725.925]

ADP Ribose Transferases Preferred

Concept UI: M0408809
Related Numbers: 81457-93-4; EC 2.4.2.31
Scope Note: Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.
Terms: ADP Ribose Transferases Preferred Term
Term UI T475147
Date12/28/2001
LexicalTag ACX
ThesaurusID NLM (2003); ADP Ribose Transferase
Term UI T032542
Date09/16/1986
LexicalTag NON
ThesaurusID UNK (19XX); ARTase
Term UI T471641
Date11/30/2001
LexicalTag ACX
ThesaurusID NLM (2003); ART Transferase
Term UI T472387
Date12/06/2001
LexicalTag ACX
ThesaurusID NLM (2003); ART Transferases
Term UI T475370
Date12/31/2001
LexicalTag ACX
ThesaurusID NLM (2003); ARTases
Term UI T475371
Date12/31/2001
LexicalTag ACX
ThesaurusID NLM (2003); ADPRT
Term UI T476738
Date01/09/2002
LexicalTag ACR
ThesaurusID NLM (2003); ADP-Ribosyltransferase
Term UI T032534
Date12/08/1987
LexicalTag NON
ThesaurusID UNK (19XX); ADPRTs
Term UI T479020
Date01/24/2002
LexicalTag ACX
ThesaurusID NLM (2003)

NAD(P)(+)-Arginine ADP-Ribosyltransferase Narrower

Concept UI: M0023658
Scope Note: An enzyme that catalyzes the transfer of the ADP-ribose moiety from NAD+ or NADP+ to specific protein substrates with arginine, arginine-type compounds, agmatine, or guanidine as acceptors. This mono-ADP-ribosylation reaction is the mechanism of action common to several bacterial toxins affecting profound changes in cellular metabolism, such as activation of adenylate cyclase, regulation of protein synthesis at the level of elongation factor 2, and ion transport across biological membranes.
Terms: NAD(P)(+)-Arginine ADP-Ribosyltransferase Preferred Term
Term UI T045248
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1989); NAD-Arginine ADP-Ribosyltransferase
Term UI T045245
Date12/31/1990
LexicalTag ACX
ThesaurusID NLM (1992); NADP-ADPRTase
Term UI T045246
Date06/03/1988
LexicalTag ACX
ThesaurusID UNK (19XX); NAD-Agmatine ADP-Ribosyltransferase
Term UI T045249
Date04/24/1991
LexicalTag ACX
ThesaurusID NLM (1992); NADP-Arginine ADP-Ribosyltransferase
Term UI T045250
Date06/03/1988
LexicalTag ACX
ThesaurusID UNK (19XX); NAD(+)-L-arginine ADP-D-ribosyltransferase
Term UI T478980
Date01/24/2002
LexicalTag ACX
ThesaurusID NLM (2003)

Mono(ADP-Ribose) Transferases Narrower

Concept UI: M0412050
Scope Note: Enzymes that catalyze the transfer of one ADP-ribose moiety from NAD+ to an amino acid residue in specific protein substrates. This reaction is catalyzed by prokaryotic and eukaryotic enzymes. Mono-ADP-ribosylation is a mechanism of action common to several bacterial toxins.
Terms: Mono(ADP-Ribose) Transferases Preferred Term
Term UI T478981
Date01/24/2002
LexicalTag ACX
ThesaurusID NLM (2003); Mono(ADP-Ribose) Transferase
Term UI T478982
Date01/24/2002
LexicalTag ACX
ThesaurusID NLM (2003); Mono ADPribose Transferases
Term UI T479021
Date01/24/2002
LexicalTag ACX
ThesaurusID NLM (2003); Mono ADPribose Transferase
Term UI T479022
Date01/24/2002
LexicalTag ACX
ThesaurusID NLM (2003); Mono ADP-ribose Transferases
Term UI T479023
Date01/24/2002
LexicalTag ACX
ThesaurusID NLM (2003); Mono(ADP-Ribosyl)transferase
Term UI T479025
Date01/24/2002
LexicalTag ACX
ThesaurusID NLM (2003); Mono(ADPribosyl)transferase
Term UI T479026
Date01/24/2002
LexicalTag ACX
ThesaurusID NLM (2003); Mono-ADP-Ribosyltransferase
Term UI T045244
Date06/03/1988
LexicalTag ACX
ThesaurusID UNK (19XX); MonoADPribosyltransferase
Term UI T479027
Date01/24/2002
LexicalTag ACX
ThesaurusID NLM (2003)

NAD+ ADP-Ribosyltransferase Narrower

ADP Ribose Transferases MeSH Descriptor Data 2024