MeSH Browser

MeSH Heading: Hypoxanthine Phosphoribosyltransferase
Tree Number(s): D08.811.913.400.725.450
Unique ID: D007041
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007041
Annotation: /defic: consider also LESCH-NYHAN SYNDROME or GOUT
Scope Note: An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
Entry Term(s): Guanine Phosphoribosyltransferase; HGPRT; HPRT; HPRTase; Hypoxanthine-Guanine Phosphoribosyltransferase; IMP Pyrophosphorylase
Related Numbers: 9016-12-0
CAS Type 1 Name: IMP:pyrophosphate phospho-D-ribosyltransferase
Previous Indexing: Pentosephosphates (1972-1974); Pentosyltransferases (1972-1974)
See Also: Gout; Lesch-Nyhan Syndrome
Public MeSH Note: 75; GUANINE PHOSPHORIBOSYLTRANSFERASE was indexed under PENTOSYLTRANSFERASES 1978-91
Online Note: use HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE (NM) to search GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1980-91
History Note: 75; GUANINE PHOSPHORIBOSYLTRANSFERASE was GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1978-91
Date Established: 1975/09/01
Date of Entry: 1974/11/11
Revision Date: 2019/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0010952
Related Numbers: 9016-12-0
Scope Note: An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
Terms: Hypoxanthine Phosphoribosyltransferase Preferred Term
Term UI T021074
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Hypoxanthine-Guanine Phosphoribosyltransferase
Term UI T021075
Date11/11/1974
LexicalTag NON
ThesaurusID NLM (1975); IMP Pyrophosphorylase
Term UI T021076
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Guanine Phosphoribosyltransferase
Term UI T021077
Date02/12/1991
LexicalTag NON
ThesaurusID NLM (1992); HPRT
Term UI T021078
Date09/09/1992
LexicalTag ABB
ThesaurusID NLM (1994); HPRTase
Term UI T021079
Date08/12/1992
LexicalTag NON
ThesaurusID NLM (1994); HGPRT
Term UI T021080
Date05/01/1997
LexicalTag ABB
ThesaurusID NLM (1998)

Hypoxanthine Phosphoribosyltransferase MeSH Descriptor Data 2024