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Heavy Chain Disease MeSH Descriptor Data 2022


MeSH Heading
Heavy Chain Disease
Tree Number(s)
C15.378.147.780.490
C15.604.515.435
C20.683.780.490
Unique ID
D006362
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D006362
Annotation
specify the immunoglobulin fragment coord NIM, as gamma chain dis = HEAVY CHAIN DISEASE (IM) + IMMUNOGLOBULIN GAMMA-CHAINS (NIM); ALPHA-CHAIN DISEASE see IMMUNOPROLIFERATIVE SMALL INTESTINAL DISEASE is available
Scope Note
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
Entry Version
HEAVY CHAIN DIS
Entry Term(s)
Franklin Disease
Franklin's Disease
gamma-Chain Disease
mu-Chain Disease
See Also
Immunoglobulin Heavy Chains
Public MeSH Note
66
History Note
66(64)
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2005/07/01
Heavy Chain Disease Preferred
mu-Chain Disease Narrower
gamma-Chain Disease Related
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