MeSH Browser

MeSH Heading: Langerhans Cells
Tree Number(s): A11.066.270.500; A11.436.270.545; A15.382.066.270.500; A15.382.670.260.500
Unique ID: D007801
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007801
Annotation: cutaneous cells: do not confuse with ISLETS OF LANGERHANS (pancreas) nor with GIANT CELLS, LANGHANS (macrophages)
Scope Note: Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.
Entry Term(s): Dendritic Cells, Dermal; Dendritic Cells, Epidermal; Dendritic Cells, Skin; Dermal Dendritic Cells; Epidermal Dendritic Cells; Langerhans Cell; Skin Dendritic Cells
Previous Indexing: Cytoplasmic Granules (1966-1968); Epithelium (1966-1968); Skin (1966-1968)
Public MeSH Note: 73
History Note: 73(69)
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27

Allowable Qualifiers: chemistry (CH)

classification (CL)

cytology (CY)

drug effects (DE)

enzymology (EN)

immunology (IM)

metabolism (ME)

microbiology (MI)

parasitology (PS)

pathology (PA)

physiology (PH)

radiation effects (RE)

transplantation (TR)

ultrastructure (UL)

virology (VI)

Concept UI: M0012200
Scope Note: Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.
Terms: Langerhans Cells Preferred Term
Term UI T023339
Date01/01/1999
LexicalTag EPO
ThesaurusID NLM (1969); Langerhans Cell
Term UI T000996509
Date11/15/2019
LexicalTag NON
ThesaurusID NLM (2021); Epidermal Dendritic Cells
Term UI T690686
Date02/01/2007
LexicalTag NON
ThesaurusID NLM (2008); Dendritic Cells, Epidermal
Term UI T690687
Date02/01/2007
LexicalTag NON
ThesaurusID NLM (2008)

Langerhans Cells MeSH Descriptor Data 2024