MeSH Browser

MeSH Heading: 15-Oxoprostaglandin 13-Reductase
Tree Number(s): D08.811.682.660.490
Unique ID: D011452
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011452
Scope Note: (5Z)-(15S)-11 alpha-Hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta(13)-oxidoreductase. An enzyme active in prostaglandin E and F catabolism. It catalyzes the reduction of the double bond at the 13-14 position of the 15-ketoprostaglandins and uses NADPH as cofactor. EC 1.3.1.48.
Entry Version: OXOPG REDUCTASE
Entry Term(s): 15-Ketoprostaglandin delta 13-Reductase; Prostaglandin delta-13-Reductase; Prostaglandin-13,14-Reductase; delta 13-15-Ketoprostaglandin Reductase; delta-13-PG-Reductase
Previous Indexing: Oxidoreductases (1966-1977); Prostaglandins (1966-1977); specific prostaglandin (1975-1977)
Public MeSH Note: 94; was PROSTAGLANDIN-13,14-REDUCTASE 1978-93 (see under OXIDOREDUCTASES 1978-90); DELTA 13-15-KETOPROSTAGLANDIN REDUCTASE was indexed under PROSTAGLANDIN-13,14-REDUCTASE 1981-93 and OXIDOREDUCTASES & PROSTAGLANDINS 1976-80; PROSTAGLANDIN DELTA 13 REDUCTASE was indexed under OXIDOREDUCTASES 1981-93
Online Note: use 15-OXOPROSTAGLANDIN 13-REDUCTASE to search PROSTAGLANDIN-13,14-REDUCTASE 1978-93; use 15-OXOPROSTAGLANDIN 13-REDUCTASE (NM) to search DELTA 13-15-KETOPROSTAGLANDIN REDUCTASE 1980-93 & PROSTAGLANDIN DELTA 13 REDUCTASE 1981-93
History Note: 94; was PROSTAGLANDIN-13,14-REDUCTASE 1978-93 (see under OXIDOREDUCTASES 1978-90); DELTA 13-15-KETOPROSTAGLANDIN REDUCTASE was (NM) 1976-93; PROSTAGLANDIN DELTA 13 REDUCTASE was (NM) 1981-93
Date Established: 1991/01/01
Date of Entry: 1977/05/23
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Oxidoreductases [D08.811.682]
    - Oxidoreductases Acting on CH-CH Group Donors [D08.811.682.660]

15-Oxoprostaglandin 13-Reductase Preferred

Concept UI: M0017804
Scope Note: (5Z)-(15S)-11 alpha-Hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta(13)-oxidoreductase. An enzyme active in prostaglandin E and F catabolism. It catalyzes the reduction of the double bond at the 13-14 position of the 15-ketoprostaglandins and uses NADPH as cofactor. EC 1.3.1.48.
Terms: 15-Oxoprostaglandin 13-Reductase Preferred Term
Term UI T033824
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1978); delta-13-PG-Reductase
Term UI T033819
Date05/19/1981
LexicalTag NON
ThesaurusID UNK (19XX); Prostaglandin delta-13-Reductase
Term UI T033820
Date05/23/1977
LexicalTag NON
ThesaurusID UNK (19XX); Prostaglandin-13,14-Reductase
Term UI T033821
Date02/08/1993
LexicalTag NON
ThesaurusID NLM (1994); delta 13-15-Ketoprostaglandin Reductase
Term UI T033822
Date02/08/1993
LexicalTag NON
ThesaurusID NLM (1994); 15-Ketoprostaglandin delta 13-Reductase
Term UI T033823
Date02/08/1993
LexicalTag NON
ThesaurusID NLM (1994)

15-Oxoprostaglandin 13-Reductase MeSH Descriptor Data 2024