NLM Logo

Pyruvate Dehydrogenase Complex MeSH Descriptor Data 2022


MeSH Heading
Pyruvate Dehydrogenase Complex
Tree Number(s)
D05.500.562.625
D08.811.600.741
Unique ID
D011768
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D011768
Scope Note
A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Registry Number
0
Previous Indexing
Oxidoreductases (1966-1972)
Pyruvate Oxidase (1966-1972)
Pyruvates (1966-1972)
Public MeSH Note
74
History Note
74(73)
Entry Combination
deficiency:Pyruvate Dehydrogenase Complex Deficiency Disease
Date Established
1974/01/01
Date of Entry
1999/01/01
Revision Date
2008/07/08
Pyruvate Dehydrogenase Complex Preferred
page delivered in 0.146s