MeSH Browser

MeSH Heading: Tosylphenylalanyl Chloromethyl Ketone
Tree Number(s): D02.065.884.060.936; D02.455.426.559.389.085.936; D02.455.426.559.389.832.710; D02.886.590.700.090.936; D02.886.590.887.660; D12.125.065.930
Unique ID: D014108
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D014108
Scope Note: An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
Entry Term(s): Chlorophenyltosylamidobutanone; TPCK; Tosylphenylalanyl Chloromethane
Pharm Action: Alkylating Agents
Protein Synthesis Inhibitors
Serine Proteinase Inhibitors
Registry Number: 402-71-1
CAS Type 1 Name: Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-, (S)-
Previous Indexing: Chlorine (1974); Phenylalanine (1972-1974); Tosyl Compounds (1973-1974)
Public MeSH Note: 91; was see under AMINO ACID CHLOROMETHYL KETONES 1977-90; was see under PHENYLALANINE 1975-76
History Note: 91(75); was see under AMINO ACID CHLOROMETHYL KETONES 1977-90; was see under PHENYLALANINE 1975-76
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2023/06/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Organic Chemicals [D02]
- Amides [D02.065]
  - Sulfonamides [D02.065.884]
    - Benzenesulfonamides [D02.065.884.060]

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Hydrocarbons, Cyclic [D02.455.426]
    - Hydrocarbons, Aromatic [D02.455.426.559]
      - Benzene Derivatives [D02.455.426.559.389]
        
        Benzenesulfonamides [D02.455.426.559.389.085]
        
        Acetohexamide [D02.455.426.559.389.085.003]
        
        Bosentan [D02.455.426.559.389.085.005]
        
        Carbutamide [D02.455.426.559.389.085.010]
        
        Celecoxib [D02.455.426.559.389.085.020]
        
        Chlorpropamide [D02.455.426.559.389.085.040]
        
        Chlorthalidone [D02.455.426.559.389.085.050]
        
        Gliclazide [D02.455.426.559.389.085.100]
        
        Mafenide [D02.455.426.559.389.085.150]
        
        Sulfachlorpyridazine [D02.455.426.559.389.085.160]
        
        Sulfadiazine [D02.455.426.559.389.085.170]
        
        Sulfadimethoxine [D02.455.426.559.389.085.180]
        
        Sulfadoxine [D02.455.426.559.389.085.190]
        
        Sulfaguanidine [D02.455.426.559.389.085.200]
        
        Sulfalene [D02.455.426.559.389.085.210]
        
        Sulfamerazine [D02.455.426.559.389.085.220]
        
        Sulfameter [D02.455.426.559.389.085.230]
        
        Sulfamethazine [D02.455.426.559.389.085.240]
        
        Sulfamethizole [D02.455.426.559.389.085.250]
        
        Sulfamethoxazole [D02.455.426.559.389.085.300]
        
        Sulfamethoxypyridazine [D02.455.426.559.389.085.325]
        
        Sulfamonomethoxine [D02.455.426.559.389.085.338]
        
        Sulfamoxole [D02.455.426.559.389.085.344]
        
        Sulfanilamide [D02.455.426.559.389.085.350]
        
        Sulfaphenazole [D02.455.426.559.389.085.400]
        
        Sulfapyridine [D02.455.426.559.389.085.450]
        
        Sulfaquinoxaline [D02.455.426.559.389.085.500]
        
        Sulfathiazole [D02.455.426.559.389.085.550]
        
        Sulfisomidine [D02.455.426.559.389.085.600]
        
        Sulfisoxazole [D02.455.426.559.389.085.650]
        
        Tamsulosin [D02.455.426.559.389.085.700]
        
        Tolazamide [D02.455.426.559.389.085.740]
        
        Tolbutamide [D02.455.426.559.389.085.745]
        
        Tosyllysine Chloromethyl Ketone [D02.455.426.559.389.085.872]
        
        Tosylphenylalanyl Chloromethyl Ketone [D02.455.426.559.389.085.936]

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Hydrocarbons, Cyclic [D02.455.426]
    - Hydrocarbons, Aromatic [D02.455.426.559]
      - Benzene Derivatives [D02.455.426.559.389]
        
        Toluene [D02.455.426.559.389.832]
        
        Bromcresol Green [D02.455.426.559.389.832.140]
        
        Bromcresol Purple [D02.455.426.559.389.832.150]
        
        Bromphenol Blue [D02.455.426.559.389.832.180]
        
        Bromthymol Blue [D02.455.426.559.389.832.200]
        
        Toluene 2,4-Diisocyanate [D02.455.426.559.389.832.500]
        
        Toluidines [D02.455.426.559.389.832.559]
        
        Tosyl Compounds [D02.455.426.559.389.832.661]
        
        Tosylarginine Methyl Ester [D02.455.426.559.389.832.670]
        
        Tosyllysine Chloromethyl Ketone [D02.455.426.559.389.832.690]
        
        Tosylphenylalanyl Chloromethyl Ketone [D02.455.426.559.389.832.710]
        
        Trifluralin [D02.455.426.559.389.832.767]
        
        Trinitrotoluene [D02.455.426.559.389.832.868]

Organic Chemicals [D02]
- Sulfur Compounds [D02.886]
  - Sulfones [D02.886.590]
    - Sulfonamides [D02.886.590.700]
      - Benzenesulfonamides [D02.886.590.700.090]
        
        Acetohexamide [D02.886.590.700.090.003]
        
        Bosentan [D02.886.590.700.090.005]
        
        Carbutamide [D02.886.590.700.090.010]
        
        Celecoxib [D02.886.590.700.090.020]
        
        Chlorpropamide [D02.886.590.700.090.040]
        
        Chlorthalidone [D02.886.590.700.090.050]
        
        Gliclazide [D02.886.590.700.090.100]
        
        Mafenide [D02.886.590.700.090.150]
        
        Sulfachlorpyridazine [D02.886.590.700.090.160]
        
        Sulfadiazine [D02.886.590.700.090.170]
        
        Sulfadimethoxine [D02.886.590.700.090.180]
        
        Sulfadoxine [D02.886.590.700.090.190]
        
        Sulfaguanidine [D02.886.590.700.090.200]
        
        Sulfalene [D02.886.590.700.090.210]
        
        Sulfamerazine [D02.886.590.700.090.220]
        
        Sulfameter [D02.886.590.700.090.230]
        
        Sulfamethazine [D02.886.590.700.090.240]
        
        Sulfamethizole [D02.886.590.700.090.250]
        
        Sulfamethoxazole [D02.886.590.700.090.300]
        
        Sulfamethoxypyridazine [D02.886.590.700.090.325]
        
        Sulfamonomethoxine [D02.886.590.700.090.338]
        
        Sulfamoxole [D02.886.590.700.090.344]
        
        Sulfanilamide [D02.886.590.700.090.350]
        
        Sulfaphenazole [D02.886.590.700.090.400]
        
        Sulfapyridine [D02.886.590.700.090.450]
        
        Sulfaquinoxaline [D02.886.590.700.090.500]
        
        Sulfathiazole [D02.886.590.700.090.550]
        
        Sulfisomidine [D02.886.590.700.090.600]
        
        Sulfisoxazole [D02.886.590.700.090.650]
        
        Tamsulosin [D02.886.590.700.090.700]
        
        Tolazamide [D02.886.590.700.090.740]
        
        Tolbutamide [D02.886.590.700.090.745]
        
        Tosyllysine Chloromethyl Ketone [D02.886.590.700.090.872]
        
        Tosylphenylalanyl Chloromethyl Ketone [D02.886.590.700.090.936]

Organic Chemicals [D02]
- Sulfur Compounds [D02.886]
  - Sulfones [D02.886.590]
    - Tosyl Compounds [D02.886.590.887]

Amino Acids, Peptides, and Proteins [D12]
- Amino Acids [D12.125]
  - Amino Acid Chloromethyl Ketones [D12.125.065]
    - Tosyllysine Chloromethyl Ketone [D12.125.065.850]
    - Tosylphenylalanyl Chloromethyl Ketone [D12.125.065.930]

Tosylphenylalanyl Chloromethyl Ketone Preferred

Concept UI: M0021715
Registry Number: 402-71-1
Scope Note: An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
Terms: Tosylphenylalanyl Chloromethyl Ketone Preferred Term
Term UI T041350
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Chlorophenyltosylamidobutanone
Term UI T041348
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Tosylphenylalanyl Chloromethane
Term UI T041349
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); TPCK
Term UI T041351
Date05/17/1976
LexicalTag ABB
ThesaurusID UNK (19XX)

Tosylphenylalanyl Chloromethyl Ketone MeSH Descriptor Data 2024