Chlorthalidone MeSH Descriptor Data 2024

MeSH Heading: Chlorthalidone
Tree Number(s): D02.065.884.060.050; D02.455.426.559.389.085.050; D02.455.426.559.389.134.500; D02.478.600.500; D02.522.223.500; D02.886.590.700.090.050; D02.886.590.700.365; D03.633.100.513.750.500
Unique ID: D002752
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002752
Scope Note: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Entry Term(s): Chlorphthalidolone; Chlortalidone; Hygroton; Oxodoline; Phthalamudine; Thalitone
Pharm Action: Antihypertensive Agents
Diuretics
Sodium Chloride Symporter Inhibitors
Related Numbers: 77-36-1
CAS Type 1 Name: Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2023/06/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Organic Chemicals [D02]
- Amides [D02.065]
  - Sulfonamides [D02.065.884]
    - Benzenesulfonamides [D02.065.884.060]

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Hydrocarbons, Cyclic [D02.455.426]
    - Hydrocarbons, Aromatic [D02.455.426.559]
      - Benzene Derivatives [D02.455.426.559.389]
        
        Benzenesulfonamides [D02.455.426.559.389.085]
        
        Acetohexamide [D02.455.426.559.389.085.003]
        
        Bosentan [D02.455.426.559.389.085.005]
        
        Carbutamide [D02.455.426.559.389.085.010]
        
        Celecoxib [D02.455.426.559.389.085.020]
        
        Chlorpropamide [D02.455.426.559.389.085.040]
        
        Chlorthalidone [D02.455.426.559.389.085.050]
        
        Gliclazide [D02.455.426.559.389.085.100]
        
        Mafenide [D02.455.426.559.389.085.150]
        
        Sulfachlorpyridazine [D02.455.426.559.389.085.160]
        
        Sulfadiazine [D02.455.426.559.389.085.170]
        
        Sulfadimethoxine [D02.455.426.559.389.085.180]
        
        Sulfadoxine [D02.455.426.559.389.085.190]
        
        Sulfaguanidine [D02.455.426.559.389.085.200]
        
        Sulfalene [D02.455.426.559.389.085.210]
        
        Sulfamerazine [D02.455.426.559.389.085.220]
        
        Sulfameter [D02.455.426.559.389.085.230]
        
        Sulfamethazine [D02.455.426.559.389.085.240]
        
        Sulfamethizole [D02.455.426.559.389.085.250]
        
        Sulfamethoxazole [D02.455.426.559.389.085.300]
        
        Sulfamethoxypyridazine [D02.455.426.559.389.085.325]
        
        Sulfamonomethoxine [D02.455.426.559.389.085.338]
        
        Sulfamoxole [D02.455.426.559.389.085.344]
        
        Sulfanilamide [D02.455.426.559.389.085.350]
        
        Sulfaphenazole [D02.455.426.559.389.085.400]
        
        Sulfapyridine [D02.455.426.559.389.085.450]
        
        Sulfaquinoxaline [D02.455.426.559.389.085.500]
        
        Sulfathiazole [D02.455.426.559.389.085.550]
        
        Sulfisomidine [D02.455.426.559.389.085.600]
        
        Sulfisoxazole [D02.455.426.559.389.085.650]
        
        Tamsulosin [D02.455.426.559.389.085.700]
        
        Tolazamide [D02.455.426.559.389.085.740]
        
        Tolbutamide [D02.455.426.559.389.085.745]
        
        Tosyllysine Chloromethyl Ketone [D02.455.426.559.389.085.872]
        
        Tosylphenylalanyl Chloromethyl Ketone [D02.455.426.559.389.085.936]

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Hydrocarbons, Cyclic [D02.455.426]
    - Hydrocarbons, Aromatic [D02.455.426.559]
      - Benzene Derivatives [D02.455.426.559.389]
        
        Benzophenones [D02.455.426.559.389.134]
        
        Chlorthalidone [D02.455.426.559.389.134.500]
        
        Fenofibrate [D02.455.426.559.389.134.750]
        
        Tolcapone [D02.455.426.559.389.134.875]

Organic Chemicals [D02]
- Imides [D02.478]
  - Phthalimides [D02.478.600]
    - Chlorthalidone [D02.478.600.500]

Organic Chemicals [D02]
- Ketones [D02.522]
  - Benzophenones [D02.522.223]

Organic Chemicals [D02]
- Sulfur Compounds [D02.886]
  - Sulfones [D02.886.590]
    - Sulfonamides [D02.886.590.700]
      - Benzenesulfonamides [D02.886.590.700.090]
        
        Acetohexamide [D02.886.590.700.090.003]
        
        Bosentan [D02.886.590.700.090.005]
        
        Carbutamide [D02.886.590.700.090.010]
        
        Celecoxib [D02.886.590.700.090.020]
        
        Chlorpropamide [D02.886.590.700.090.040]
        
        Chlorthalidone [D02.886.590.700.090.050]
        
        Gliclazide [D02.886.590.700.090.100]
        
        Mafenide [D02.886.590.700.090.150]
        
        Sulfachlorpyridazine [D02.886.590.700.090.160]
        
        Sulfadiazine [D02.886.590.700.090.170]
        
        Sulfadimethoxine [D02.886.590.700.090.180]
        
        Sulfadoxine [D02.886.590.700.090.190]
        
        Sulfaguanidine [D02.886.590.700.090.200]
        
        Sulfalene [D02.886.590.700.090.210]
        
        Sulfamerazine [D02.886.590.700.090.220]
        
        Sulfameter [D02.886.590.700.090.230]
        
        Sulfamethazine [D02.886.590.700.090.240]
        
        Sulfamethizole [D02.886.590.700.090.250]
        
        Sulfamethoxazole [D02.886.590.700.090.300]
        
        Sulfamethoxypyridazine [D02.886.590.700.090.325]
        
        Sulfamonomethoxine [D02.886.590.700.090.338]
        
        Sulfamoxole [D02.886.590.700.090.344]
        
        Sulfanilamide [D02.886.590.700.090.350]
        
        Sulfaphenazole [D02.886.590.700.090.400]
        
        Sulfapyridine [D02.886.590.700.090.450]
        
        Sulfaquinoxaline [D02.886.590.700.090.500]
        
        Sulfathiazole [D02.886.590.700.090.550]
        
        Sulfisomidine [D02.886.590.700.090.600]
        
        Sulfisoxazole [D02.886.590.700.090.650]
        
        Tamsulosin [D02.886.590.700.090.700]
        
        Tolazamide [D02.886.590.700.090.740]
        
        Tolbutamide [D02.886.590.700.090.745]
        
        Tosyllysine Chloromethyl Ketone [D02.886.590.700.090.872]
        
        Tosylphenylalanyl Chloromethyl Ketone [D02.886.590.700.090.936]

Organic Chemicals [D02]
- Sulfur Compounds [D02.886]
  - Sulfones [D02.886.590]
    - Sulfonamides [D02.886.590.700]

Heterocyclic Compounds [D03]
- Heterocyclic Compounds, Fused-Ring [D03.633]
  - Heterocyclic Compounds, 2-Ring [D03.633.100]
    - Isoindoles [D03.633.100.513]
      - Phthalimides [D03.633.100.513.750]
        
        Chlorthalidone [D03.633.100.513.750.500]
        
        Lenalidomide [D03.633.100.513.750.563]
        
        Phosmet [D03.633.100.513.750.625]
        
        Thalidomide [D03.633.100.513.750.750]

Chlorthalidone Preferred

Concept UI: M0004215
Related Numbers: 77-36-1
Scope Note: A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
Terms: Chlorthalidone Preferred Term
Term UI T007994
Date01/01/1999
LexicalTag NON
ThesaurusID; Oxodoline
Term UI T007995
Date07/31/1980
LexicalTag NON
ThesaurusID UNK (19XX); Phthalamudine
Term UI T007996
Date03/30/1977
LexicalTag NON
ThesaurusID UNK (19XX); Chlorphthalidolone
Term UI T007993
Date03/30/1977
LexicalTag NON
ThesaurusID UNK (19XX); Chlortalidone
Term UI T007998
Date11/14/1996
LexicalTag NON
ThesaurusID

Hygroton Narrower

Thalitone Narrower

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