MeSH Browser

MeSH Heading: Uroporphyrinogen III Synthetase
Tree Number(s): D08.811.520.241.300.950
Unique ID: D014576
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D014576
Scope Note: An enzyme that catalyzes the cyclization of hydroxymethylbilane to yield UROPORPHYRINOGEN III and water. It is the fourth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by UROS gene. Mutations of UROS gene result in CONGENITAL ERYTHROPOIETIC PORPHYRIA.
Entry Term(s): Cosynthase; Uroporphyrinogen III Cosynthetase; Uroporphyrinogen Isomerase; Uroporphyrinogen-III Synthase
Related Numbers: 37340-55-9
CAS Type 1 Name: Hydroxymethylbilane hydro-lyase (cyclizing)
Previous Indexing: Isomerases (1971-1974); Porphobilinogen (1973-1974)
See Also: Porphyria, Erythropoietic
Public MeSH Note: 2005; see UROPORPHYRINOGEN-III SYNTHASE 1998-2004, see UROPORPHYRINOGEN III SYNTHASE 1991-1997, see HYDRO-LYASES 1985-1990, see ISOMERASES 1975-1984
History Note: 2005 (1975)
Entry Combination: deficiency:Porphyria, Erythropoietic
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2009/07/06

Entry Combination: deficiency:Porphyria, Erythropoietic
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0022407
Related Numbers: 37340-55-9
Scope Note: An enzyme that catalyzes the cyclization of hydroxymethylbilane to yield UROPORPHYRINOGEN III and water. It is the fourth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by UROS gene. Mutations of UROS gene result in CONGENITAL ERYTHROPOIETIC PORPHYRIA.
Terms: Uroporphyrinogen III Synthetase Preferred Term
Term UI T042646
Date02/07/1984
LexicalTag NON
ThesaurusID UNK (19XX); Cosynthase
Term UI T042642
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Uroporphyrinogen III Cosynthetase
Term UI T042643
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Uroporphyrinogen Isomerase
Term UI T042645
Date04/16/1984
LexicalTag NON
ThesaurusID UNK (19XX); Uroporphyrinogen-III Synthase
Term UI T042644
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975)

Uroporphyrinogen III Synthetase MeSH Descriptor Data 2024